{"id":28239,"date":"2025-03-27T21:50:15","date_gmt":"2025-03-27T20:50:15","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/harnessing-microglia-based-cell-therapies-for-the-treatment-of-neurodegenerative-diseases\/"},"modified":"2025-03-27T21:50:15","modified_gmt":"2025-03-27T20:50:15","slug":"harnessing-microglia-based-cell-therapies-for-the-treatment-of-neurodegenerative-diseases","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/harnessing-microglia-based-cell-therapies-for-the-treatment-of-neurodegenerative-diseases\/","title":{"rendered":"Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Mar 25;94:102552. doi: 10.1016\/j.coi.2025.102552. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Given the growing evidence linking microglia to the onset and progression of various neurodegenerative diseases, these brain-resident macrophages have emerged as a promising cell type for targeted therapeutic interventions. This review highlights recent studies that utilized innovative, microglia-focused strategies for the treatment of diverse neurodegenerative disorders including lysosomal storage disorders, granulin frontotemporal dementia, and Alzheimer&#8217;s disease. Cutting-edge therapeutic strategies range from replacing faulty microglia with peripheral macrophage precursors or induced human pluripotent stem cell-derived microglia to engineering microglia that target toxic aggregates or deliver remediating payloads. We also examine the potential limitations as well as the clinical benefits of these strategies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40138748\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250327165014&amp;v=2.18.0.post9+e462414\">40138748<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102552\">10.1016\/j.coi.2025.102552<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Mar 25;94:102552. doi: 10.1016\/j.coi.2025.102552. Online ahead of print. ABSTRACT Given the growing evidence linking microglia to the onset and progression of various neurodegenerative diseases, these brain-resident macrophages have emerged as a promising cell type for targeted therapeutic interventions. This review highlights recent studies that utilized innovative, microglia-focused strategies for the treatment &#8230; <a title=\"Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/harnessing-microglia-based-cell-therapies-for-the-treatment-of-neurodegenerative-diseases\/\" aria-label=\"Read more about Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-28239","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=28239"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28239\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=28239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=28239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=28239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}