{"id":28912,"date":"2025-04-04T18:47:47","date_gmt":"2025-04-04T16:47:47","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/04\/lung-resident-memory-cd4-t-cells-are-dependent-on-batf3\/"},"modified":"2025-04-04T18:47:47","modified_gmt":"2025-04-04T16:47:47","slug":"lung-resident-memory-cd4-t-cells-are-dependent-on-batf3","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/04\/lung-resident-memory-cd4-t-cells-are-dependent-on-batf3\/","title":{"rendered":"Lung-resident memory CD4+ T cells are dependent on Batf3"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 4:vkaf035. doi: 10.1093\/jimmun\/vkaf035. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Tissue-resident memory cells contribute to allergen-induced inflammation and airway hyperresponsiveness, but relatively little is known of the cellular and molecular mechanisms underlying the accumulation of these cells in the lung. Here, we show that allergen-specific CD4+ resident memory T cells are virtually absent in lungs of mice lacking Batf3, a transcription factor required for the development of type 1 lung dendritic cells (cDC1). These animals become sensitized to inhaled allergens and display normal responses in a short-term house dust mite-dependent model of asthma. However, they have strongly reduced airway inflammation and weak airway hyperresponsiveness in a similar, but long-term model of asthma. Single-cell RNA sequencing revealed that Batf3-deficient mice lack a subset of lung-resident CD4+ T cells characterized by expression of the chemokine receptor-encoding gene, Cxcr6. Together, these data show that Batf3 promotes the development of CD4+ resident memory T cells and thus allergic responses to inhaled allergens.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40184040\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250404124747&amp;v=2.18.0.post9+e462414\">40184040<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf035\">10.1093\/jimmun\/vkaf035<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 4:vkaf035. doi: 10.1093\/jimmun\/vkaf035. Online ahead of print. ABSTRACT Tissue-resident memory cells contribute to allergen-induced inflammation and airway hyperresponsiveness, but relatively little is known of the cellular and molecular mechanisms underlying the accumulation of these cells in the lung. Here, we show that allergen-specific CD4+ resident memory T cells are virtually absent &#8230; <a title=\"Lung-resident memory CD4+ T cells are dependent on Batf3\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/04\/lung-resident-memory-cd4-t-cells-are-dependent-on-batf3\/\" aria-label=\"Read more about Lung-resident memory CD4+ T cells are dependent on Batf3\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-28912","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=28912"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28912\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=28912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=28912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=28912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}