{"id":30260,"date":"2025-04-16T12:47:49","date_gmt":"2025-04-16T10:47:49","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/impact-of-cd4-t-cell-and-tcr-repertoires-on-sars-cov-2-specific-antibody-responses-in-plwh-following-covid-19-vaccination\/"},"modified":"2025-04-16T12:47:49","modified_gmt":"2025-04-16T10:47:49","slug":"impact-of-cd4-t-cell-and-tcr-repertoires-on-sars-cov-2-specific-antibody-responses-in-plwh-following-covid-19-vaccination","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/impact-of-cd4-t-cell-and-tcr-repertoires-on-sars-cov-2-specific-antibody-responses-in-plwh-following-covid-19-vaccination\/","title":{"rendered":"Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 15:vkae040. doi: 10.1093\/jimmun\/vkae040. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing the differential antibody response to the COVID-19 vaccine in PLWH, 43 HIV-1\/AIDS patients receiving antiretroviral therapy (ART) and 2 doses of the COVID-19 vaccine were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immunoglobulin G (IgG) levels and neutralizing antibody (NAb) titers. A retrospective analysis was also performed, examining immune reconstitution and epidemiological history, including annual CD4+ T-cell counts and the duration of HIV-1 infection. To further elucidate the role of CD4+ T cells in the antibody response to the COVID-19 vaccine, next-generation sequencing was used to analyze the T cell receptor (TCR) profiles of CD4+ T cells from twelve representative individuals. The results showed that the SARS-CoV-2-specific antibody response in PLWH was not solely determined by the current CD4+ T cell count, the progression of immune reconstitution and the TCR profile of CD4+ T cells also played significant roles. These findings provide critical insights into the multifaceted roles of CD4+ T cells in SARS-CoV-2-specific antibody responses in PLWH following COVID-19 vaccination.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40235093\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250416064748&amp;v=2.18.0.post9+e462414\">40235093<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkae040\">10.1093\/jimmun\/vkae040<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 15:vkae040. doi: 10.1093\/jimmun\/vkae040. Online ahead of print. ABSTRACT In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humoral immune response. While a reduced absolute CD4+ T cell count is a known factor, other determinants remain unclear. To investigate variables influencing &#8230; <a title=\"Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/impact-of-cd4-t-cell-and-tcr-repertoires-on-sars-cov-2-specific-antibody-responses-in-plwh-following-covid-19-vaccination\/\" aria-label=\"Read more about Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-30260","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30260"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30260\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}