{"id":30262,"date":"2025-04-16T12:47:49","date_gmt":"2025-04-16T10:47:49","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/icos-cd4-t-cells-promote-antitumor-immunity-through-akt-stat1-t-bet-axis-in-mss-pmmr-colorectal-cancer\/"},"modified":"2025-04-16T12:47:49","modified_gmt":"2025-04-16T10:47:49","slug":"icos-cd4-t-cells-promote-antitumor-immunity-through-akt-stat1-t-bet-axis-in-mss-pmmr-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/icos-cd4-t-cells-promote-antitumor-immunity-through-akt-stat1-t-bet-axis-in-mss-pmmr-colorectal-cancer\/","title":{"rendered":"ICOS+ CD4+ T cells promote antitumor immunity through Akt\/STAT1\/T-bet axis in MSS\/pMMR colorectal cancer"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 15:vkaf040. doi: 10.1093\/jimmun\/vkaf040. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Inducible Co-Stimulator (ICOS), as a T-cell-specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial role in cancer immunity. However, its role in MSS\/pMMR colorectal cancer (CRC) remains unclear. In this study, we demonstrated that ICOS expression decreases as the tumor stages advance and that high ICOS expression is associated with a favorable prognosis in MSS\/pMMR CRC. Mechanistically, ICOS promoted the secretion of IFN-\u03b3, TNF-\u03b1, and IL-12 in CD4+ T cells through the Akt\/STAT1\/T-bet axis, leading to the inhibition of MSS\/pMMR-CRC-cell proliferation. Importantly, ICOS+ CD4+ T cells enhanced tumor responses to anti-PD-1 therapy in MSS\/pMMR CRC. In conclusion, this study revealed that ICOS mediates antitumor immunity by promoting the secretion of cancer-suppressive cytokines. It also suggests that activation of ICOS serves a potential therapeutic strategy for MSS\/pMMR CRC.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40235079\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250416064748&amp;v=2.18.0.post9+e462414\">40235079<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf040\">10.1093\/jimmun\/vkaf040<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 15:vkaf040. doi: 10.1093\/jimmun\/vkaf040. Online ahead of print. ABSTRACT Inducible Co-Stimulator (ICOS), as a T-cell-specific costimulatory receptor that enhances T-cell responses to foreign antigens, plays a crucial role in cancer immunity. However, its role in MSS\/pMMR colorectal cancer (CRC) remains unclear. In this study, we demonstrated that ICOS expression decreases as the &#8230; <a title=\"ICOS+ CD4+ T cells promote antitumor immunity through Akt\/STAT1\/T-bet axis in MSS\/pMMR colorectal cancer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/16\/icos-cd4-t-cells-promote-antitumor-immunity-through-akt-stat1-t-bet-axis-in-mss-pmmr-colorectal-cancer\/\" aria-label=\"Read more about ICOS+ CD4+ T cells promote antitumor immunity through Akt\/STAT1\/T-bet axis in MSS\/pMMR colorectal cancer\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-30262","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30262"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30262\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}