{"id":30434,"date":"2025-04-22T00:47:56","date_gmt":"2025-04-21T22:47:56","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/22\/deciphering-the-role-of-il-17d-its-newly-identified-receptor-cd93-and-il-17d-cd93-axis-in-health-and-disease\/"},"modified":"2025-04-22T00:47:56","modified_gmt":"2025-04-21T22:47:56","slug":"deciphering-the-role-of-il-17d-its-newly-identified-receptor-cd93-and-il-17d-cd93-axis-in-health-and-disease","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/22\/deciphering-the-role-of-il-17d-its-newly-identified-receptor-cd93-and-il-17d-cd93-axis-in-health-and-disease\/","title":{"rendered":"Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 21:vkaf061. doi: 10.1093\/jimmun\/vkaf061. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles in oxidative stress response and potential antitumor therapies. It is involved in autoimmune diseases, infections, and cancers, making it a promising therapeutic target. CD93 is crucial in various biological processes, from angiogenesis to inflammatory diseases. CD93&#8217;s implications in cancers, neuroinflammation, and metabolism highlight its significance as a potential prognostic marker and therapeutic target. The review emphasizes IL-17D and CD93 as promising areas for future research, offering insights into their signaling pathways and potential applications in personalized medicine. Deciphering the relationship between IL-17D and CD93 is in its infancy and invites exploration for transformative advancements in immunology and beyond.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40258301\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250421184754&amp;v=2.18.0.post9+e462414\">40258301<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf061\">10.1093\/jimmun\/vkaf061<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 21:vkaf061. doi: 10.1093\/jimmun\/vkaf061. Online ahead of print. ABSTRACT This review explores interleukin (IL)-17D and its receptor CD93, highlighting their structural, functional, and clinical aspects. Identifying CD93 as the receptor for IL-17D has advanced understanding of the IL-17 family and its signaling pathways. IL-17D, with its unique glycoprotein structure, plays diverse roles &#8230; <a title=\"Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/22\/deciphering-the-role-of-il-17d-its-newly-identified-receptor-cd93-and-il-17d-cd93-axis-in-health-and-disease\/\" aria-label=\"Read more about Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-30434","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30434"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30434\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}