{"id":30504,"date":"2025-04-23T06:47:06","date_gmt":"2025-04-23T04:47:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/23\/cd40-ligand-the-essential-link-in-b-t-cell-collaboration-and-immune-activation\/"},"modified":"2025-04-23T06:47:06","modified_gmt":"2025-04-23T04:47:06","slug":"cd40-ligand-the-essential-link-in-b-t-cell-collaboration-and-immune-activation","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/23\/cd40-ligand-the-essential-link-in-b-t-cell-collaboration-and-immune-activation\/","title":{"rendered":"CD40 ligand: the essential link in B\/T cell collaboration and immune activation"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 22:vkaf072. doi: 10.1093\/jimmun\/vkaf072. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>This Pillars of Immunology article is a commentary on 2 pivotal articles that shaped the CD40-CD40L field &#8211; &#8220;Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM,&#8221; written by U. Korth\u00e4uer, D. Graf, H.W. Mages, F. Bri\u00e8re, M. Padayachee, S. Malcolm, A.G. Ugazio, L.D. Notarangelo, R.J. Levinsky, and R.A. Kroczek, and published in Nature, in 1993. https:\/\/www.nature.com\/articles\/361539a0; and &#8220;CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM&#8221; written by J.P. DiSanto, J.Y. Bonnefoy, J.F. Gauchatt, A. Fischer, and G. de Saint Basile, and published in Nature, in 1993. https:\/\/www.nature.com\/articles\/361541a0.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40262278\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250423004705&amp;v=2.18.0.post9+e462414\">40262278<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf072\">10.1093\/jimmun\/vkaf072<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 22:vkaf072. doi: 10.1093\/jimmun\/vkaf072. Online ahead of print. ABSTRACT This Pillars of Immunology article is a commentary on 2 pivotal articles that shaped the CD40-CD40L field &#8211; &#8220;Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM,&#8221; written by U. Korth\u00e4uer, D. Graf, H.W. Mages, F. Bri\u00e8re, M. Padayachee, S. Malcolm, &#8230; <a title=\"CD40 ligand: the essential link in B\/T cell collaboration and immune activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/23\/cd40-ligand-the-essential-link-in-b-t-cell-collaboration-and-immune-activation\/\" aria-label=\"Read more about CD40 ligand: the essential link in B\/T cell collaboration and immune activation\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-30504","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30504"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30504\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}