{"id":30694,"date":"2025-04-25T01:47:16","date_gmt":"2025-04-24T23:47:16","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/25\/whats-atypical-about-human-b-cells-after-allogeneic-stem-cell-transplantationsonali-j-bracken-on-24-de-april-de-2025-at-1000\/"},"modified":"2025-04-25T01:47:16","modified_gmt":"2025-04-24T23:47:16","slug":"whats-atypical-about-human-b-cells-after-allogeneic-stem-cell-transplantationsonali-j-bracken-on-24-de-april-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/25\/whats-atypical-about-human-b-cells-after-allogeneic-stem-cell-transplantationsonali-j-bracken-on-24-de-april-de-2025-at-1000\/","title":{"rendered":"What&#8217;s Atypical about Human B cells after Allogeneic Stem Cell Transplantation?\u200bSonali J Bracken   on 24 de April de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Apr 24:qiaf048. doi: 10.1093\/jleuko\/qiaf048. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the setting of infection, multiple other studies suggest that these cells play a pathogenic role in the setting of autoimmunity. After treatment with allogeneic stem cell transplantation (HCT), the memory B cell compartment is altered in patients who develop an autoimmune-like syndrome called chronic graft-versus-host disease (cGVHD). Chronic GVHD patients have significantly increased proportions of CD11c+ ABCs within the peripheral compartment that develop under constant exposure to host alloantigens and persist under conditions when B cell tolerance is not achieved. Herein, we review what is currently known about the molecular alterations in the heterogeneous memory B cell compartment of HCT patients, especially cGVHD patients who have developed autoimmune manifestations. In this mini-review, we summarize intrinsic factors in ABCs found in autoimmune states that likely influence their extrafollicular localization, differentiation potential into autoantibody secreting cells, and function. We highlight lessons from B cell studies in cGVHD to provide unique insights into the molecular underpinnings of the diverse functions of ABCs.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40273381\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250424194715&amp;v=2.18.0.post9+e462414\">40273381<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf048\">10.1093\/jleuko\/qiaf048<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Apr 24:qiaf048. doi: 10.1093\/jleuko\/qiaf048. Online ahead of print. ABSTRACT Atypical B cells or age-associated B cells (ABCs) represent an alternative lineage of memory B cells. Emerging evidence suggests that context influences the apparent functional heterogeneity of ABCs. While data support a protective role for ABCs in the setting of infection, multiple &#8230; <a title=\"What&#8217;s Atypical about Human B cells after Allogeneic Stem Cell Transplantation?\u200bSonali J Bracken   on 24 de April de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/25\/whats-atypical-about-human-b-cells-after-allogeneic-stem-cell-transplantationsonali-j-bracken-on-24-de-april-de-2025-at-1000\/\" aria-label=\"Read more about What&#8217;s Atypical about Human B cells after Allogeneic Stem Cell Transplantation?\u200bSonali J Bracken   on 24 de April de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-30694","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30694"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30694\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}