{"id":30830,"date":"2025-04-26T10:47:11","date_gmt":"2025-04-26T08:47:11","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/26\/differential-induction-of-endoplasmic-reticulum-stress-signaling-by-antibody-isotypes-implications-for-plasma-cell-differentiation-valuekunie-obayashi-tomomitsu-doi-kazuhiro-sumida-m\/"},"modified":"2025-04-26T10:47:11","modified_gmt":"2025-04-26T08:47:11","slug":"differential-induction-of-endoplasmic-reticulum-stress-signaling-by-antibody-isotypes-implications-for-plasma-cell-differentiation-valuekunie-obayashi-tomomitsu-doi-kazuhiro-sumida-m","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/26\/differential-induction-of-endoplasmic-reticulum-stress-signaling-by-antibody-isotypes-implications-for-plasma-cell-differentiation-valuekunie-obayashi-tomomitsu-doi-kazuhiro-sumida-m\/","title":{"rendered":"Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation. [[{&#8220;value&#8221;:&#8221;Kunie Obayashi, \nTomomitsu Doi, \nKazuhiro Sumida, \nMotoyoshi Endo&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/bf54907a-d5b4-4d12-9acf-84f485a3bc6b\/eji5974-gra-0001-m.png\" alt=\"Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation\" \/><\/p>\n<p>IgE induces stronger ER stress than IgG1 due to its constant region, particularly the C\u03b53 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE&#8217;s higher BiP-binding capacity. ER stress, driven by IRE1-XBP1 signaling, regulates plasma cell differentiation, suggesting IgE-specific mechanisms in immune responses.<\/p>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>IgE induces stronger ER stress than IgG1 due to its constant region, particularly the C\u03b53 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE&#8217;s higher BiP-binding capacity. ER stress, driven by IRE1-XBP1 signaling, regulates plasma cell differentiation, suggesting IgE-specific mechanisms in immune responses.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-30830","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30830"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30830\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}