{"id":30841,"date":"2025-04-26T22:47:26","date_gmt":"2025-04-26T20:47:26","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/04\/26\/immunoregulatory-macrophages-induced-by-mycobacterial-nonpolar-lipids\/"},"modified":"2025-04-26T22:47:26","modified_gmt":"2025-04-26T20:47:26","slug":"immunoregulatory-macrophages-induced-by-mycobacterial-nonpolar-lipids","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/04\/26\/immunoregulatory-macrophages-induced-by-mycobacterial-nonpolar-lipids\/","title":{"rendered":"Immunoregulatory macrophages induced by mycobacterial nonpolar lipids"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Apr 25:vkae058. doi: 10.1093\/jimmun\/vkae058. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms, especially macrophages. Although Mtb lipids are believed to play a role in this host-pathogen crosstalk, how mycobacterial lipids drive this complex interaction is poorly characterized. Here, we cultured macrophages with nonpolar cell wall Mtb lipids and applied high-throughput expression profiling (RNA sequencing), mass spectrometry-based targeted eicosanoid, and untargeted lipidomics analysis. This system-level analysis revealed that Mtb nonpolar lipid triggered the expression of phenotypic markers for classically and alternatively activated macrophages, a state previously referred as immunoregulatory. Specifically, under lipid stimulation, macrophages expressed high levels of proinflammatory markers, activated components of the interleukin-1 family, underwent an imbalance in lipid metabolism, and shifted the eicosanoid synthesis pathway toward the prostaglandin axis. Taken together, these results suggest an intricate mechanism of Mtb-driven macrophage immunomodulation that may favor its long-term survival.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40280187\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250426164725&amp;v=2.18.0.post9+e462414\">40280187<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkae058\">10.1093\/jimmun\/vkae058<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Apr 25:vkae058. doi: 10.1093\/jimmun\/vkae058. Online ahead of print. ABSTRACT The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms, especially macrophages. Although Mtb lipids are believed to play a role in this host-pathogen crosstalk, how mycobacterial lipids drive this complex interaction is &#8230; <a title=\"Immunoregulatory macrophages induced by mycobacterial nonpolar lipids\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/04\/26\/immunoregulatory-macrophages-induced-by-mycobacterial-nonpolar-lipids\/\" aria-label=\"Read more about Immunoregulatory macrophages induced by mycobacterial nonpolar lipids\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-30841","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=30841"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/30841\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=30841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=30841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=30841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}