{"id":31881,"date":"2025-05-13T12:48:09","date_gmt":"2025-05-13T10:48:09","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/the-4-functional-segments-of-factor-h-role-in-physiological-target-recognition-and-contribution-to-disease\/"},"modified":"2025-05-13T12:48:09","modified_gmt":"2025-05-13T10:48:09","slug":"the-4-functional-segments-of-factor-h-role-in-physiological-target-recognition-and-contribution-to-disease","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/the-4-functional-segments-of-factor-h-role-in-physiological-target-recognition-and-contribution-to-disease\/","title":{"rendered":"The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 May 12:vkaf065. doi: 10.1093\/jimmun\/vkaf065. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Factor H controls proximal complement activation, and its dysfunction leads to diseases that often manifest in the kidney. Structural and functional analyses have identified 4 distinct functional segments: an N-terminal regulatory unit, a cell binding unit, a segment with combined low-affinity C3b and heparin sites, and a C-terminal recognition or sensor unit with overlapping C3b\/C3d and heparin sites. Three segments are linked to diseases. The regulatory segment is affected in C3 glomerulopathy and antineutrophil cytoplasmic antibody-associated vasculitis. The second segment includes the Y402H polymorphism of age-related macular degeneration, is associated with different types of cancer, and is targeted by pathogens. The C-terminal sensor segment is involved in atypical hemolytic uremic syndrome, in FHR1:FHR3 deficient and autoantibody-positive hemolytic uremic syndrome form and is exploited by pathogens. Factor H function is modulated by Factor H like protein 1 and FHR1, 2 plasma proteins that share segments with Factor H. This interplay is critical for fine-tuning local complement. Understanding Factor H&#8217;s physiological role, as well as the impact of its absence, mutations, or autoantibody targeting, provides insights into disease mechanisms and provides opportunities for therapeutic intervention by using full-length Factor H, its fragments, or complement-modulatory compounds.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40356067\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250513064802&amp;v=2.18.0.post9+e462414\">40356067<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf065\">10.1093\/jimmun\/vkaf065<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 May 12:vkaf065. doi: 10.1093\/jimmun\/vkaf065. Online ahead of print. ABSTRACT Factor H controls proximal complement activation, and its dysfunction leads to diseases that often manifest in the kidney. Structural and functional analyses have identified 4 distinct functional segments: an N-terminal regulatory unit, a cell binding unit, a segment with combined low-affinity C3b and &#8230; <a title=\"The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/the-4-functional-segments-of-factor-h-role-in-physiological-target-recognition-and-contribution-to-disease\/\" aria-label=\"Read more about The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-31881","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/31881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=31881"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/31881\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=31881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=31881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=31881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}