{"id":32315,"date":"2025-05-14T10:47:17","date_gmt":"2025-05-14T08:47:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/14\/escalation-of-germinal-center-responses-in-chronic-litomosoides-sigmodontis-filarial-infection-valueteresa-steffen-jesuthas-ajendra-marianne-koschel-alexander-palmen-hannah-wegner\/"},"modified":"2025-05-14T10:47:17","modified_gmt":"2025-05-14T08:47:17","slug":"escalation-of-germinal-center-responses-in-chronic-litomosoides-sigmodontis-filarial-infection-valueteresa-steffen-jesuthas-ajendra-marianne-koschel-alexander-palmen-hannah-wegner","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/14\/escalation-of-germinal-center-responses-in-chronic-litomosoides-sigmodontis-filarial-infection-valueteresa-steffen-jesuthas-ajendra-marianne-koschel-alexander-palmen-hannah-wegner\/","title":{"rendered":"Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection. [[{&#8220;value&#8221;:&#8221;Teresa Steffen, \nJesuthas Ajendra, \nMarianne Koschel, \nAlexander Palmen, \nHannah Wegner, \nFrederic Risch, \nLuisa Bach, \nManuel Ritter, \nMarc P. H\u00fcbner, \nDirk Baumjohann&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/5d62ecbc-c4ee-49c3-96cd-2f44cdfd8fc7\/eji5972-gra-0001-m.png\" alt=\"Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection\" \/><\/p>\n<p>T follicular helper (T<sub>FH<\/sub>) cells provide essential help to B cells in germinal centers (GCs). T<sub>FH<\/sub> and GC B cell responses are long-lasting in draining mediastinal lymph nodes of <i>Litomosoides sigmodontis<\/i>-infected BALB\/c mice, a rodent model of filarial infection.<\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>T follicular helper (T<sub>FH<\/sub>) cells are the primary CD4<sup>+<\/sup> T helper cell subset providing help to B cells for efficient antibody responses in vaccination, allergy, autoimmunity, and infectious diseases. Despite their critical involvement in immunity, T<sub>FH<\/sub> cells\u2019 specific role in filarial infections remains unclear. Using the rodent filarial model <i>Litomosoides sigmodontis<\/i>, we examined T<sub>FH<\/sub> and germinal center (GC) B cell responses in lung-draining mediastinal lymph nodes (medLNs) over a 110-day infection period in naive and infected wildtype (WT) BALB\/c mice, as well as eosinophil-deficient dblGATA mice, using flow cytometry and ELISA. We observed robust and prolonged T<sub>FH<\/sub> and GC B cell responses in medLNs of infected BALB\/c mice, along with enduring IgG1 antibody responses next to a persistent systemic humoral immune response. We further provide evidence of dysregulated T<sub>FH<\/sub>\/T follicular regulatory (T<sub>FR<\/sub>) cell ratios in medLNs. Finally, elevated T<sub>FH<\/sub> cell frequencies in medLNs of dblGATA mice reaffirm the significant role of eosinophils during chronic infection. In conclusion, our findings provide novel insights into population changes of T<sub>FH<\/sub> and GC B cells during filarial infection.<\/p>","protected":false},"excerpt":{"rendered":"<p>T follicular helper (TFH) cells provide essential help to B cells in germinal centers (GCs). TFH and GC B cell responses are long-lasting in draining mediastinal lymph nodes of Litomosoides sigmodontis-infected BALB\/c mice, a rodent model of filarial infection. ABSTRACT T follicular helper (TFH) cells are the primary CD4+ T helper cell subset providing help &#8230; <a title=\"Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection. [[{&#8220;value&#8221;:&#8221;Teresa Steffen, \nJesuthas Ajendra, \nMarianne Koschel, \nAlexander Palmen, \nHannah Wegner, \nFrederic Risch, \nLuisa Bach, \nManuel Ritter, \nMarc P. H\u00fcbner, \nDirk Baumjohann&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/14\/escalation-of-germinal-center-responses-in-chronic-litomosoides-sigmodontis-filarial-infection-valueteresa-steffen-jesuthas-ajendra-marianne-koschel-alexander-palmen-hannah-wegner\/\" aria-label=\"Read more about Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection. [[{&#8220;value&#8221;:&#8221;Teresa Steffen, \nJesuthas Ajendra, \nMarianne Koschel, \nAlexander Palmen, \nHannah Wegner, \nFrederic Risch, \nLuisa Bach, \nManuel Ritter, \nMarc P. H\u00fcbner, \nDirk Baumjohann&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-32315","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=32315"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32315\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=32315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=32315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=32315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}