{"id":32482,"date":"2025-05-13T12:00:00","date_gmt":"2025-05-13T10:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/deepening-understanding-of-the-clinical-features-and-diagnostic-approaches-to-anti-interferon-gamma-autoantibody-associated-adult-onset-immunodeficiency-in-the-last-20-years-a-case-report-and-literat\/"},"modified":"2025-05-13T12:00:00","modified_gmt":"2025-05-13T10:00:00","slug":"deepening-understanding-of-the-clinical-features-and-diagnostic-approaches-to-anti-interferon-gamma-autoantibody-associated-adult-onset-immunodeficiency-in-the-last-20-years-a-case-report-and-literat","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/deepening-understanding-of-the-clinical-features-and-diagnostic-approaches-to-anti-interferon-gamma-autoantibody-associated-adult-onset-immunodeficiency-in-the-last-20-years-a-case-report-and-literat\/","title":{"rendered":"Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2025 May 13;45(1):93. doi: 10.1007\/s10875-025-01885-z.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Anti-interferon-gamma autoantibody (AIGA)-associated adult-onset immunodeficiency (AOID) is an emerging disease that can lead to serious opportunistic infections, which has a history of 20 years since it was first reported in 2004. It&#8217;s a hard-detected AOID caused by AIGA. In recent years, there has been an increasing number of reports on the disease, but there is still a lack of consensus on the diagnosis and treatment. We here report a case of a 70-year-old Chinese male who had had AIGA in serum and suffered from recurrent pyothorax. Although his condition improved with antimicrobial therapy each time, his pyothorax frequently relapsed, requiring repeated hospitalizations. A literature review of AIGA-associated AOID was conducted. We searched PubMed, Web of Science, Embase, and the Chinese literature database for manuscripts concerning AIGA. Cases detected with AIGA and met our criteria were included. A total of 502 patients were retrospectively analyzed, with 256 (51.0%) males and 246 (49.0%) females. The majority of patients are from Southeast Asia (98.2%). Lymph node (83.7%) is the most commonly involved organ, followed by the lung (60.6%). Nontuberculous mycobacteria (NTM) was identified as the predominant pathogen reported in 77.49% of the patients. The clinical manifestations are diverse and non-specific for the disease often presenting with multi-organ involvement and multiple infections. Timely identification of patients with AIGA, appropriate diagnosis, and individualized treatment are critical; thus, we propose a reasonable diagnostic criterion and a structured diagnostic and treatment process based on our findings to provide clinicians with comprehensive information for clinical practice.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40360799\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20250514114918&amp;v=2.18.0.post9+e462414\">40360799<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-025-01885-z\">10.1007\/s10875-025-01885-z<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2025 May 13;45(1):93. doi: 10.1007\/s10875-025-01885-z. ABSTRACT Anti-interferon-gamma autoantibody (AIGA)-associated adult-onset immunodeficiency (AOID) is an emerging disease that can lead to serious opportunistic infections, which has a history of 20 years since it was first reported in 2004. It&#8217;s a hard-detected AOID caused by AIGA. In recent years, there has been an increasing &#8230; <a title=\"Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/13\/deepening-understanding-of-the-clinical-features-and-diagnostic-approaches-to-anti-interferon-gamma-autoantibody-associated-adult-onset-immunodeficiency-in-the-last-20-years-a-case-report-and-literat\/\" aria-label=\"Read more about Deepening Understanding of the Clinical Features and Diagnostic Approaches to Anti-Interferon-Gamma Autoantibody Associated Adult-Onset Immunodeficiency in the Last 20 Years: A Case Report and Literature Review\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-32482","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=32482"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32482\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=32482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=32482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=32482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}