{"id":32688,"date":"2025-05-16T00:47:45","date_gmt":"2025-05-15T22:47:45","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/16\/cerebrospinal-fluid-immune-phenotyping-reveals-distinct-immunotypes-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome\/"},"modified":"2025-05-16T00:47:45","modified_gmt":"2025-05-15T22:47:45","slug":"cerebrospinal-fluid-immune-phenotyping-reveals-distinct-immunotypes-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/16\/cerebrospinal-fluid-immune-phenotyping-reveals-distinct-immunotypes-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome\/","title":{"rendered":"Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis\/chronic fatigue syndrome"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 May 15:vkaf087. doi: 10.1093\/jimmun\/vkaf087. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals&#8217; quality of life. Diagnosis of ME\/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful subtypes. The heterogeneity in the literature suggests that individuals living with ME\/CFS may suffer from overlapping but different underlying pathophysiological mechanisms. We enrolled 40 participants with ME\/CFS and 41 matched healthy control subjects at the Brag\u00e9e Clinic in Sweden. We assessed plasma samples from both ME\/CFS cases and control groups and cerebrospinal fluid (CSF) samples from individuals with ME\/CFS. We investigated dysregulated pathways and disease profiles through clinical questionnaires; multiplex analyses of cytokines, hormones, and matrix metalloproteinases; pathogen seroreactivity through peptide display bacteria libraries; and high-throughput microarray for autoantibodies. All samples used were from humans. We show altered interaction patterns between circulating biological factors in plasma of ME\/CFS participants. Our analysis of CSF from individuals with ME\/CFS revealed different immunotypes of disease. We found 2 patient clusters based on matrix metalloproteinases profiles. The subgroups had similar clinical presentation but distinct pathogen exposure and CSF inflammatory profiles. Our findings shed light on ME\/CFS immune phenotypes and generate hypotheses for future research in disease pathogenesis and treatment development by exploring disease subgroups.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40373264\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250515184738&amp;v=2.18.0.post9+e462414\">40373264<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf087\">10.1093\/jimmun\/vkaf087<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 May 15:vkaf087. doi: 10.1093\/jimmun\/vkaf087. Online ahead of print. ABSTRACT Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals&#8217; quality of life. Diagnosis of ME\/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful subtypes. The heterogeneity &#8230; <a title=\"Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis\/chronic fatigue syndrome\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/16\/cerebrospinal-fluid-immune-phenotyping-reveals-distinct-immunotypes-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome\/\" aria-label=\"Read more about Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis\/chronic fatigue syndrome\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-32688","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=32688"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32688\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=32688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=32688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=32688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}