{"id":32852,"date":"2025-05-18T23:47:06","date_gmt":"2025-05-18T21:47:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/causes-and-consequences-of-t-cell-dna-damage-costas-koufaris\/"},"modified":"2025-05-18T23:47:06","modified_gmt":"2025-05-18T21:47:06","slug":"causes-and-consequences-of-t-cell-dna-damage-costas-koufaris","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/causes-and-consequences-of-t-cell-dna-damage-costas-koufaris\/","title":{"rendered":"Causes and consequences of T cell DNA damage. Costas Koufaris"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 May 16:S1471-4906(25)00119-X. doi: 10.1016\/j.it.2025.04.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Although DNA damage is a common cellular event, T cells experience significant genotoxic stresses because of rapid antigen-stimulated expansion and their presence in various nonlymphoid microenvironments. In addition to the well-established link between genomic instability and malignancy, recent genomic studies have uncovered a substantial mutational burden in nonmalignant T cells in both normal aging and disease contexts. Furthermore, genomic damage in T cells is accelerated in autoimmune diseases and in older individuals because of both intrinsic and extrinsic factors. This review highlights the different genotoxic stressors affecting T cells and the detrimental effects of persistent DNA damage and identifies the most critical knowledge gaps.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40382245\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250518174659&amp;v=2.18.0.post9+e462414\">40382245<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.04.006\">10.1016\/j.it.2025.04.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 May 16:S1471-4906(25)00119-X. doi: 10.1016\/j.it.2025.04.006. Online ahead of print. ABSTRACT Although DNA damage is a common cellular event, T cells experience significant genotoxic stresses because of rapid antigen-stimulated expansion and their presence in various nonlymphoid microenvironments. In addition to the well-established link between genomic instability and malignancy, recent genomic studies have uncovered a &#8230; <a title=\"Causes and consequences of T cell DNA damage. Costas Koufaris\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/causes-and-consequences-of-t-cell-dna-damage-costas-koufaris\/\" aria-label=\"Read more about Causes and consequences of T cell DNA damage. Costas Koufaris\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-32852","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=32852"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32852\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=32852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=32852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=32852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}