{"id":32854,"date":"2025-05-18T23:47:09","date_gmt":"2025-05-18T21:47:09","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/mice-deficient-of-g-protein-coupled-receptor-3-gpr3-developed-severe-experimental-autoimmune-uveitis-eau-through-increased-effector-t-cell-activities\/"},"modified":"2025-05-18T23:47:09","modified_gmt":"2025-05-18T21:47:09","slug":"mice-deficient-of-g-protein-coupled-receptor-3-gpr3-developed-severe-experimental-autoimmune-uveitis-eau-through-increased-effector-t-cell-activities","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/mice-deficient-of-g-protein-coupled-receptor-3-gpr3-developed-severe-experimental-autoimmune-uveitis-eau-through-increased-effector-t-cell-activities\/","title":{"rendered":"Mice deficient of G-protein coupled receptor 3 (GPR3) developed severe experimental autoimmune uveitis (EAU) through increased effector T cell activities"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 May 17:vkaf099. doi: 10.1093\/jimmun\/vkaf099. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>We discovered a protective role of G protein-coupled receptor 3 (GPR3) in a mouse model of T cell-mediated autoimmune uveitis. GPR3 is an orphan receptor that maintains Gs-coupling and cyclic AMP production without an exogenous ligand. Consequently, GPR3 deficient (GPR3KO) mice were more susceptible to developing experimental autoimmune uveitis (EAU) induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) or by adoptive transfer of IRBP-specific T cells than their wild type (WT) littermates. T cells isolated from IRBP-immunized GPR3KO mice demonstrated an increase in proliferation and inflammatory cytokine production in response to the specific IRBP antigen and a relatively high resistance to activation-induced T cell death compared to T cells isolated from immunized WT mice. Moreover, a major tight junction protein such as ZO-1 was reduced in GPR3 deficient retina with severe uveitis after IRBP-specific T cells were transferred. Taken together, our findings suggest that constitutively active GPR3 inhibits T cell mediated retinal inflammation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40381994\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250518174702&amp;v=2.18.0.post9+e462414\">40381994<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf099\">10.1093\/jimmun\/vkaf099<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 May 17:vkaf099. doi: 10.1093\/jimmun\/vkaf099. Online ahead of print. ABSTRACT We discovered a protective role of G protein-coupled receptor 3 (GPR3) in a mouse model of T cell-mediated autoimmune uveitis. GPR3 is an orphan receptor that maintains Gs-coupling and cyclic AMP production without an exogenous ligand. Consequently, GPR3 deficient (GPR3KO) mice were more &#8230; <a title=\"Mice deficient of G-protein coupled receptor 3 (GPR3) developed severe experimental autoimmune uveitis (EAU) through increased effector T cell activities\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/18\/mice-deficient-of-g-protein-coupled-receptor-3-gpr3-developed-severe-experimental-autoimmune-uveitis-eau-through-increased-effector-t-cell-activities\/\" aria-label=\"Read more about Mice deficient of G-protein coupled receptor 3 (GPR3) developed severe experimental autoimmune uveitis (EAU) through increased effector T cell activities\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-32854","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=32854"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/32854\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=32854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=32854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=32854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}