{"id":33003,"date":"2025-05-20T12:46:59","date_gmt":"2025-05-20T10:46:59","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/20\/mir-125b-5p-sensitizes-colorectal-cancer-to-anti-pd-l1-therapy-by-decreasing-tnfr2-expression-on-tumor-cellsyibo-chen-on-20-de-may-de-2025-at-1000\/"},"modified":"2025-05-20T12:46:59","modified_gmt":"2025-05-20T10:46:59","slug":"mir-125b-5p-sensitizes-colorectal-cancer-to-anti-pd-l1-therapy-by-decreasing-tnfr2-expression-on-tumor-cellsyibo-chen-on-20-de-may-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/20\/mir-125b-5p-sensitizes-colorectal-cancer-to-anti-pd-l1-therapy-by-decreasing-tnfr2-expression-on-tumor-cellsyibo-chen-on-20-de-may-de-2025-at-1000\/","title":{"rendered":"miR-125b-5p sensitizes colorectal cancer to anti-PD-L1 therapy by decreasing TNFR2 expression on tumor cells\u200bYibo Chen   on 20 de May de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 May 20:qiaf059. doi: 10.1093\/jleuko\/qiaf059. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The micro-RNA miR-125b-5p, recognized as a tumor suppressor, has demonstrated the ability to curb the proliferation of various types of cancer cells. Our latest research has revealed that miR-125b-5p also impedes the proliferation and functionality of CD4+Foxp3+ regulatory T cells (Tregs) by reducing the expression of tumor necrosis factor receptor \u2161 (TNFR2) on Tregs. To explore the potential of miR-125b-5p to suppress tumor growth by targeting TNFR2 on cancer cells, we overexpressed the levels of miR-125b-5p in mouse colorectal cancer cells. Our findings showed that the overexpression of miR-125b-5p significantly suppressed the proliferation, migration, and invasiveness of TNFR2-expressing cancer cells. This was further supported by in vivo observations, where we noted a regression of 20-30% of tumors in immunocompetent mice that had been treated with miR-125b-5p-overexpressing cells. Remarkably, when combined with anti-PD-L1 therapy, the regression rate increased dramatically, with over 85% of mice showing a 2- to 3-fold enhancement in tumor regression. This synergistic effect was attributed to the miR-125b-5p-mediated increase in cytotoxic CD8+ T cells. In conclusion, our study suggests that miR-125b-5p, by inhibiting TNFR2 expression in colorectal cancer cells, can enhance the effectiveness of anti-PD-L1 immunotherapy. This is achieved by modulating anti-tumor immune responses. The potential of miR-125b-5p to boost the efficacy of immunotherapies in clinical settings is a promising avenue for future therapeutic development.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40391464\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250520064651&amp;v=2.18.0.post9+e462414\">40391464<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf059\">10.1093\/jleuko\/qiaf059<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 May 20:qiaf059. doi: 10.1093\/jleuko\/qiaf059. Online ahead of print. ABSTRACT The micro-RNA miR-125b-5p, recognized as a tumor suppressor, has demonstrated the ability to curb the proliferation of various types of cancer cells. Our latest research has revealed that miR-125b-5p also impedes the proliferation and functionality of CD4+Foxp3+ regulatory T cells (Tregs) by &#8230; <a title=\"miR-125b-5p sensitizes colorectal cancer to anti-PD-L1 therapy by decreasing TNFR2 expression on tumor cells\u200bYibo Chen   on 20 de May de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/20\/mir-125b-5p-sensitizes-colorectal-cancer-to-anti-pd-l1-therapy-by-decreasing-tnfr2-expression-on-tumor-cellsyibo-chen-on-20-de-may-de-2025-at-1000\/\" aria-label=\"Read more about miR-125b-5p sensitizes colorectal cancer to anti-PD-L1 therapy by decreasing TNFR2 expression on tumor cells\u200bYibo Chen   on 20 de May de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-33003","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33003"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33003\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}