{"id":33171,"date":"2025-05-22T06:47:34","date_gmt":"2025-05-22T04:47:34","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/22\/can-we-cure-igg4-related-diseases\/"},"modified":"2025-05-22T06:47:34","modified_gmt":"2025-05-22T04:47:34","slug":"can-we-cure-igg4-related-diseases","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/22\/can-we-cure-igg4-related-diseases\/","title":{"rendered":"&#8216;Can we cure IgG4-related diseases?&#8217;"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 May 20;95:102564. doi: 10.1016\/j.coi.2025.102564. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>IgG4-related disease (IgG4-RD), recognized as a novel clinical entity, is a rare, chronic, immune-mediated systemic fibroinflammatory disorder of unknown origin with either synchronous or metachronous multi-organ involvement. Although the pathogenic mechanism remains unclear, possible multipathogenic factors such as genetic backgrounds, disease-specific or related antigens, and abnormal innate or adaptive immunity may be involved. Many immunocytes, including neutrophil extracellular trap, M2 macrophage, plasmablast, B cells, and T-cells (Th2-CD4<sup>+<\/sup>T, follicular helper T cells, and CD4<sup>+<\/sup>SLAMF7<sup>+<\/sup>cytotoxic T cells) play important roles in the pathogenesis. Conventional therapies with glucocorticoid or rituximab in combination with\/without immunomodulators are recommended in all symptomatic patients with active IgG4-RD. Because of a few of randomized clinical trials, the comprehensive management for IgG4-RD has not been established yet. Targeted treatment approaches against the plasmablast to B cell lineage and the CD4<sup>+<\/sup>SLAMF7<sup>+<\/sup>cytotoxic T cell seem to be promising for the future-directed treatment.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40398200\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250522004726&amp;v=2.18.0.post9+e462414\">40398200<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102564\">10.1016\/j.coi.2025.102564<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 May 20;95:102564. doi: 10.1016\/j.coi.2025.102564. Online ahead of print. ABSTRACT IgG4-related disease (IgG4-RD), recognized as a novel clinical entity, is a rare, chronic, immune-mediated systemic fibroinflammatory disorder of unknown origin with either synchronous or metachronous multi-organ involvement. Although the pathogenic mechanism remains unclear, possible multipathogenic factors such as genetic backgrounds, disease-specific or &#8230; <a title=\"&#8216;Can we cure IgG4-related diseases?&#8217;\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/22\/can-we-cure-igg4-related-diseases\/\" aria-label=\"Read more about &#8216;Can we cure IgG4-related diseases?&#8217;\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-33171","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33171"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33171\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}