{"id":33369,"date":"2025-05-26T06:48:35","date_gmt":"2025-05-26T04:48:35","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/26\/inflammatory-chemokine-receptors-ccr1-ccr2-ccr3-and-ccr5-are-essential-for-an-optimal-t-cell-response-to-influenza-marieke-pingen\/"},"modified":"2025-05-26T06:48:35","modified_gmt":"2025-05-26T04:48:35","slug":"inflammatory-chemokine-receptors-ccr1-ccr2-ccr3-and-ccr5-are-essential-for-an-optimal-t-cell-response-to-influenza-marieke-pingen","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/26\/inflammatory-chemokine-receptors-ccr1-ccr2-ccr3-and-ccr5-are-essential-for-an-optimal-t-cell-response-to-influenza-marieke-pingen\/","title":{"rendered":"Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza. Marieke Pingen"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 May 23:S1933-0219(25)00052-2. doi: 10.1016\/j.mucimm.2025.05.005. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Inflammatory chemokine receptors CCR1\/2\/3\/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) challenge to investigate the combinatorial roles of the iCCRs in the anti-IAV immune response. We did not observe any gross differences in infection-driven pathology in the absence of iCCRs. iCCR deletion resulted in decreased numbers of some antigen-presenting cell types in the lung (B cells, DC1s, monocytes and inflammatory macrophages), though cell numbers in the draining lymph node were not affected. Whilst the total number of T cells was similar in lungs of iCCR-deficient mice, the number of IAV-specific CD4 but not CD8 T cells in the lung was strongly reduced in the absence of iCCRs. Furthermore, fewer CD4, but not CD8, T cells produced IFN-\u03b3. This CD4 T cell phenotype persisted into the memory stage of infection, with fewer IAV-specific and IFN-\u03b3<sup>+<\/sup> CD4 but not CD8 T cells at 29 days post infection. In conclusion, despite having limited impact on antigen-presenting cell migration between the lung and the draining lymph node, iCCR deletion is associated with an altered CD4 T cell response to IAV infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40414601\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250526004827&amp;v=2.18.0.post9+e462414\">40414601<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.05.005\">10.1016\/j.mucimm.2025.05.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 May 23:S1933-0219(25)00052-2. doi: 10.1016\/j.mucimm.2025.05.005. Online ahead of print. ABSTRACT Inflammatory chemokine receptors CCR1\/2\/3\/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here we utilise an influenza A virus (IAV) challenge to investigate the combinatorial roles of the iCCRs &#8230; <a title=\"Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza. Marieke Pingen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/26\/inflammatory-chemokine-receptors-ccr1-ccr2-ccr3-and-ccr5-are-essential-for-an-optimal-t-cell-response-to-influenza-marieke-pingen\/\" aria-label=\"Read more about Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza. Marieke Pingen\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-33369","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33369"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33369\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}