{"id":33539,"date":"2025-05-28T00:47:35","date_gmt":"2025-05-27T22:47:35","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/from-killers-to-hoplites-neutrophils-in-skin-barrier-defenseaustin-lowery-on-27-de-may-de-2025-at-1000\/"},"modified":"2025-05-28T00:47:35","modified_gmt":"2025-05-27T22:47:35","slug":"from-killers-to-hoplites-neutrophils-in-skin-barrier-defenseaustin-lowery-on-27-de-may-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/from-killers-to-hoplites-neutrophils-in-skin-barrier-defenseaustin-lowery-on-27-de-may-de-2025-at-1000\/","title":{"rendered":"From Killers to Hoplites: Neutrophils in Skin Barrier Defense\u200bAustin Lowery   on 27 de May de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 May 27:qiaf074. doi: 10.1093\/jleuko\/qiaf074. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Neutrophils are traditionally known as short-lived pathogen-killing cells, but recent work published in Nature by Hidalgo and colleagues uncovers a novel role for neutrophils in maintaining skin integrity. Using transcriptomics, imaging, and genetic models, the study reveals that skin-infiltrating neutrophils produce collagen, particularly COL3A1, to regulate tissue mechanics and form matrix-rich &#8220;shields&#8221; that prevent pathogen entry. Collagen production by these specialized neutrophils in the skin was TGF\u03b2-dependent and essential for wound protection, as its disruption led to disorganized skin architecture and increased bacterial invasion. This work redefines neutrophils as dynamic matrix-builders in barrier tissues, offering new insights into immune-tissue crosstalk and advancing our understanding of wound healing and host defense.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40424586\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250527184726&amp;v=2.18.0.post9+e462414\">40424586<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf074\">10.1093\/jleuko\/qiaf074<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 May 27:qiaf074. doi: 10.1093\/jleuko\/qiaf074. Online ahead of print. ABSTRACT Neutrophils are traditionally known as short-lived pathogen-killing cells, but recent work published in Nature by Hidalgo and colleagues uncovers a novel role for neutrophils in maintaining skin integrity. Using transcriptomics, imaging, and genetic models, the study reveals that skin-infiltrating neutrophils produce collagen, &#8230; <a title=\"From Killers to Hoplites: Neutrophils in Skin Barrier Defense\u200bAustin Lowery   on 27 de May de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/from-killers-to-hoplites-neutrophils-in-skin-barrier-defenseaustin-lowery-on-27-de-may-de-2025-at-1000\/\" aria-label=\"Read more about From Killers to Hoplites: Neutrophils in Skin Barrier Defense\u200bAustin Lowery   on 27 de May de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-33539","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33539"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33539\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}