{"id":33551,"date":"2025-05-28T06:47:09","date_gmt":"2025-05-28T04:47:09","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/mait-cells-exacerbate-colonic-inflammation-in-a-genetically-diverse-murine-model-of-spontaneous-colitis-liyen-loh\/"},"modified":"2025-05-28T06:47:09","modified_gmt":"2025-05-28T04:47:09","slug":"mait-cells-exacerbate-colonic-inflammation-in-a-genetically-diverse-murine-model-of-spontaneous-colitis-liyen-loh","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/mait-cells-exacerbate-colonic-inflammation-in-a-genetically-diverse-murine-model-of-spontaneous-colitis-liyen-loh\/","title":{"rendered":"MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Liyen Loh"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 May 25:S1933-0219(25)00053-4. doi: 10.1016\/j.mucimm.2025.05.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and Th17 lineages, are increasingly recognized for their roles in mucosal immunity. Here, we identified the Collaborative-Cross CC011\/Unc strain, which spontaneously develops chronic colitis, as being enriched for MAIT cells. This expansion coincides with an age-related loss of intestinal barrier permeability and colonic inflammation. Microbiota from CC011 mice activated MAIT cells in an MR1-dependent manner and selectively promoted the accumulation of MAIT17 cells in peripheral tissues. Single-cell transcriptomic analyses revealed colon MAIT cells from colitic CC011 mice expressed a pathogenic Th17-like signature, characterized by IL-1 and IL-23 signaling, IL-17A and IFN\u03b3 co-expression, and upregulation of IL-23R, features that correlated with inflammatory Ly6C<sup>hi<\/sup> monocyte abundance. Genetic deletion of Traj33, essential for MAIT development, significantly reduced colonic inflammation in this model. These findings demonstrate that MAIT cells integrate microbial and cytokine cues to adopt a pathogenic effector phenotype that exacerbates chronic intestinal inflammation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40425090\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250528004700&amp;v=2.18.0.post9+e462414\">40425090<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.05.006\">10.1016\/j.mucimm.2025.05.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 May 25:S1933-0219(25)00053-4. doi: 10.1016\/j.mucimm.2025.05.006. Online ahead of print. ABSTRACT IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and Th17 lineages, are increasingly recognized for their roles in mucosal immunity. &#8230; <a title=\"MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Liyen Loh\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/28\/mait-cells-exacerbate-colonic-inflammation-in-a-genetically-diverse-murine-model-of-spontaneous-colitis-liyen-loh\/\" aria-label=\"Read more about MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis. Liyen Loh\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-33551","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33551"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33551\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}