{"id":33620,"date":"2025-05-29T06:48:04","date_gmt":"2025-05-29T04:48:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/05\/29\/restraining-the-killers-regulation-of-t-cell-quiescence-molly-e-lumnitzer\/"},"modified":"2025-05-29T06:48:04","modified_gmt":"2025-05-29T04:48:04","slug":"restraining-the-killers-regulation-of-t-cell-quiescence-molly-e-lumnitzer","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/05\/29\/restraining-the-killers-regulation-of-t-cell-quiescence-molly-e-lumnitzer\/","title":{"rendered":"Restraining the killers: regulation of T cell quiescence. Molly E Lumnitzer"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 May 27:S1471-4906(25)00121-8. doi: 10.1016\/j.it.2025.04.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Active regulation of T cell quiescence is important to sustain immune responses to vaccination and infection while preventing inappropriate responses such as autoimmunity. Recent studies highlight that quiescence in na\u00efve T cells is actively regulated by transcription factors and tonic signaling. Loss of quiescence in aged T cells has significant consequences because the cells are less responsive to infection or vaccination. This review covers the current state of knowledge about transcriptional regulation of na\u00efve T cell quiescence and how quiescence is lost in aged hosts and during chronic infection. Finally, we discuss the need for a deeper understanding of the factors involved in cell quiescence to identify targets to restore cell quiescence in dysfunctional T cells.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40436650\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250529004804&amp;v=2.18.0.post9+e462414\">40436650<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.04.008\">10.1016\/j.it.2025.04.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 May 27:S1471-4906(25)00121-8. doi: 10.1016\/j.it.2025.04.008. Online ahead of print. ABSTRACT Active regulation of T cell quiescence is important to sustain immune responses to vaccination and infection while preventing inappropriate responses such as autoimmunity. Recent studies highlight that quiescence in na\u00efve T cells is actively regulated by transcription factors and tonic signaling. Loss of &#8230; <a title=\"Restraining the killers: regulation of T cell quiescence. Molly E Lumnitzer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/05\/29\/restraining-the-killers-regulation-of-t-cell-quiescence-molly-e-lumnitzer\/\" aria-label=\"Read more about Restraining the killers: regulation of T cell quiescence. Molly E Lumnitzer\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-33620","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=33620"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/33620\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=33620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=33620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=33620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}