{"id":34146,"date":"2025-06-04T18:51:56","date_gmt":"2025-06-04T16:51:56","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/04\/arginine-metabolism-supports-metabolic-reprogramming-in-trained-immunitylaura-m-merlo-pich-on-4-de-june-de-2025-at-1000\/"},"modified":"2025-06-04T18:51:56","modified_gmt":"2025-06-04T16:51:56","slug":"arginine-metabolism-supports-metabolic-reprogramming-in-trained-immunitylaura-m-merlo-pich-on-4-de-june-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/04\/arginine-metabolism-supports-metabolic-reprogramming-in-trained-immunitylaura-m-merlo-pich-on-4-de-june-de-2025-at-1000\/","title":{"rendered":"Arginine metabolism supports metabolic reprogramming in trained immunity\u200bLaura M Merlo Pich   on 4 de June de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Jun 4:qiaf080. doi: 10.1093\/jleuko\/qiaf080. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Trained immunity, also termed innate immune memory, is supported by metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains largely unexplored. Primary human monocytes were trained with \u03b2-glucan in a medium enriched with or deprived of arginine or supplemented with an arginase inhibitor. After a resting period, trained cells were restimulated with LPS. Arginine deprivation or arginase inhibition during \u03b2-glucan-training impaired the amplification of IL-6 and TNF cytokine response to LPS, while they did not affect the cells&#8217; phagocytotic capacity. Arginine deprivation also significantly reduced the oxygen consumption rate of trained cells, without affecting glycolysis. Genetic studies revealed polymorphisms near genes coding for arginine-metabolizing enzymes modulated induction of trained immunity, highlighting the role of arginine-derived metabolites in trained immunity. These findings demonstrate that arginine and its metabolites are involved in the induction of trained immunity. Understanding metabolic mechanisms involved in trained immunity could provide insights into new therapeutic strategies for harnessing arginine deprivation to modulate inflammatory disorders.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40464645\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250604125155&amp;v=2.18.0.post9+e462414\">40464645<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf080\">10.1093\/jleuko\/qiaf080<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Jun 4:qiaf080. doi: 10.1093\/jleuko\/qiaf080. Online ahead of print. ABSTRACT Trained immunity, also termed innate immune memory, is supported by metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains &#8230; <a title=\"Arginine metabolism supports metabolic reprogramming in trained immunity\u200bLaura M Merlo Pich   on 4 de June de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/04\/arginine-metabolism-supports-metabolic-reprogramming-in-trained-immunitylaura-m-merlo-pich-on-4-de-june-de-2025-at-1000\/\" aria-label=\"Read more about Arginine metabolism supports metabolic reprogramming in trained immunity\u200bLaura M Merlo Pich   on 4 de June de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-34146","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/34146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=34146"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/34146\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=34146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=34146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=34146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}