{"id":34341,"date":"2025-06-07T00:47:04","date_gmt":"2025-06-06T22:47:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/07\/granulocyte-function-in-response-to-acute-alcohol-consumption-temporal-shifts-from-pro-inflammatory-activation-to-anti-inflammatory-modulation-in-healthy-volunteersramona-sturm-on-6-de-jun\/"},"modified":"2025-06-07T00:47:04","modified_gmt":"2025-06-06T22:47:04","slug":"granulocyte-function-in-response-to-acute-alcohol-consumption-temporal-shifts-from-pro-inflammatory-activation-to-anti-inflammatory-modulation-in-healthy-volunteersramona-sturm-on-6-de-jun","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/07\/granulocyte-function-in-response-to-acute-alcohol-consumption-temporal-shifts-from-pro-inflammatory-activation-to-anti-inflammatory-modulation-in-healthy-volunteersramona-sturm-on-6-de-jun\/","title":{"rendered":"Granulocyte Function in Response to Acute Alcohol Consumption: Temporal Shifts from Pro-Inflammatory Activation to Anti-Inflammatory Modulation in Healthy Volunteers\u200bRamona Sturm   on 6 de June de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Jun 6:qiaf081. doi: 10.1093\/jleuko\/qiaf081. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>While chronic alcohol use is proinflammatory, the immune effects of acute intake remain unclear. We examined granulocyte responses to binge drinking, common in youth. Twenty-two volunteers consumed 12 alcoholic drinks over 4h (BAC 1.0\u2030). Blood was collected at baseline (T0), 2h (T2), 4h (T4), 6h (T6), 24h (T24), and 48h (T48) post-intake. IL-6 and M30 (inflammation, cell death) were analyzed by ELISA; CXCL10 and MPO gene expression in PMNLs by qRT-PCR; CD62L and TLR4 on CD16+ granulocytes by flow cytometry; inflammasome activation post-LPS\/ATP stimulation; and PMNL-adhesion to A549 lung cells. IL-6 increased significantly at T2-T6; M30 peaked at T4, decreasing at T24-T48. CXCL10 and MPO increased at T2-T4; MPO declined at T24-T48. TLR4-positive granulocytes increased at T2-T4. Active caspase-1 rose over 48h, while stimulated activation declined at T4, T24. CD62L increased at T2 before declining. PMNL-adhesion decreased significantly at T24-T48. Acute alcohol triggers early inflammation followed by immune suppression.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40479504\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250606184703&amp;v=2.18.0.post9+e462414\">40479504<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf081\">10.1093\/jleuko\/qiaf081<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Jun 6:qiaf081. doi: 10.1093\/jleuko\/qiaf081. Online ahead of print. ABSTRACT While chronic alcohol use is proinflammatory, the immune effects of acute intake remain unclear. We examined granulocyte responses to binge drinking, common in youth. Twenty-two volunteers consumed 12 alcoholic drinks over 4h (BAC 1.0\u2030). Blood was collected at baseline (T0), 2h (T2), &#8230; <a title=\"Granulocyte Function in Response to Acute Alcohol Consumption: Temporal Shifts from Pro-Inflammatory Activation to Anti-Inflammatory Modulation in Healthy Volunteers\u200bRamona Sturm   on 6 de June de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/07\/granulocyte-function-in-response-to-acute-alcohol-consumption-temporal-shifts-from-pro-inflammatory-activation-to-anti-inflammatory-modulation-in-healthy-volunteersramona-sturm-on-6-de-jun\/\" aria-label=\"Read more about Granulocyte Function in Response to Acute Alcohol Consumption: Temporal Shifts from Pro-Inflammatory Activation to Anti-Inflammatory Modulation in Healthy Volunteers\u200bRamona Sturm   on 6 de June de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-34341","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/34341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=34341"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/34341\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=34341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=34341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=34341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}