{"id":35129,"date":"2025-06-12T06:48:29","date_gmt":"2025-06-12T04:48:29","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/12\/dysbiosis-of-the-gut-microbiome-may-contribute-to-the-pathogenesis-of-oral-lichen-planus-through-treg-dysregulation-shiho-yokomizo\/"},"modified":"2025-06-12T06:48:29","modified_gmt":"2025-06-12T04:48:29","slug":"dysbiosis-of-the-gut-microbiome-may-contribute-to-the-pathogenesis-of-oral-lichen-planus-through-treg-dysregulation-shiho-yokomizo","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/12\/dysbiosis-of-the-gut-microbiome-may-contribute-to-the-pathogenesis-of-oral-lichen-planus-through-treg-dysregulation-shiho-yokomizo\/","title":{"rendered":"Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation. Shiho Yokomizo"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Jun 9:S1933-0219(25)00055-8. doi: 10.1016\/j.mucimm.2025.05.009. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4<sup>+<\/sup> T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, where CD4<sup>+<\/sup> T cells play a significant role. Given these insights, the development of OLP might be influenced by dysbiosis. This study investigates the association between dysbiosis and CD4<sup>+<\/sup> T cells in OLP. We collected stool and saliva samples from OLP patients, conducting 16S rRNA gene analysis and mass spectrometry, and assessed CD4<sup>+<\/sup> T cell characteristics in lesions through multiplex immunofluorescence and single-cell RNA sequencing. Peripheral blood samples were subjected to flow cytometry and cell culture assays. Results showed extensive gut dysbiosis in OLP patients, notably a reduction in short-chain fatty acid (SCFA)-producing bacteria essential for regulatory T cell (Treg) differentiation. While various CD4<sup>+<\/sup> T cell subsets, including Tregs, were present in tissues, these Tregs as unresponsive to specific antigens, showing reduced immunosuppressive molecule expression. The decline in SCFA-producing bacteria correlated with fewer activated Tregs in tissues and blood. These findings suggest that gut dysbiosis may contribute to OLP by impairing Treg regulation, influencing disease pathogenesis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40499683\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250612004827&amp;v=2.18.0.post9+e462414\">40499683<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.05.009\">10.1016\/j.mucimm.2025.05.009<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Jun 9:S1933-0219(25)00055-8. doi: 10.1016\/j.mucimm.2025.05.009. Online ahead of print. ABSTRACT Oral lichen planus (OLP) is a chronic inflammatory disorder with autoimmune features and malignant transformation risk, lacking a definitive treatment, with CD4+ T cells being pivotal in its pathogenesis. Dysbiosis, an imbalance in the microbiome, is linked to various autoimmune and inflammatory diseases, &#8230; <a title=\"Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation. Shiho Yokomizo\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/12\/dysbiosis-of-the-gut-microbiome-may-contribute-to-the-pathogenesis-of-oral-lichen-planus-through-treg-dysregulation-shiho-yokomizo\/\" aria-label=\"Read more about Dysbiosis of the gut microbiome may contribute to the pathogenesis of oral lichen planus through Treg dysregulation. Shiho Yokomizo\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-35129","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=35129"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35129\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=35129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=35129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=35129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}