{"id":35321,"date":"2025-06-13T06:50:24","date_gmt":"2025-06-13T04:50:24","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/13\/a-review-of-spatial-transcriptomics-in-psoriasis-new-insights-into-cellular-contributions\/"},"modified":"2025-06-13T06:50:24","modified_gmt":"2025-06-13T04:50:24","slug":"a-review-of-spatial-transcriptomics-in-psoriasis-new-insights-into-cellular-contributions","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/13\/a-review-of-spatial-transcriptomics-in-psoriasis-new-insights-into-cellular-contributions\/","title":{"rendered":"A review of spatial transcriptomics in psoriasis: new insights into cellular contributions"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Jun 11;95:102585. doi: 10.1016\/j.coi.2025.102585. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Spatial transcriptomics (ST) is a technology that has advanced our understanding of the cellular and genetic characteristics of conditions like psoriasis, cancer, and neurodegenerative diseases. ST is often used in conjunction with methods like single-cell RNA sequencing (scRNA-seq), which is a popular method to investigate cellular gene expression. Together, ST and scRNA-seq allow for the visualization and quantification of gene expression spatially, with the preservation of tissue architecture. In psoriasis research, ST and scRNA-seq have led to the identification of distinct cell populations within the skin, associated dysregulated pathways, and critical insight into tissue microenvironments and cell-to-cell interactions. In this review, we provide a summary of how ST has been utilized to better understand psoriasis and how it has shaped our understanding of prominent cell types in psoriasis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40505496\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250613005023&amp;v=2.18.0.post9+e462414\">40505496<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102585\">10.1016\/j.coi.2025.102585<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Jun 11;95:102585. doi: 10.1016\/j.coi.2025.102585. Online ahead of print. ABSTRACT Spatial transcriptomics (ST) is a technology that has advanced our understanding of the cellular and genetic characteristics of conditions like psoriasis, cancer, and neurodegenerative diseases. ST is often used in conjunction with methods like single-cell RNA sequencing (scRNA-seq), which is a popular &#8230; <a title=\"A review of spatial transcriptomics in psoriasis: new insights into cellular contributions\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/13\/a-review-of-spatial-transcriptomics-in-psoriasis-new-insights-into-cellular-contributions\/\" aria-label=\"Read more about A review of spatial transcriptomics in psoriasis: new insights into cellular contributions\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-35321","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=35321"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35321\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=35321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=35321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=35321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}