{"id":35417,"date":"2025-06-15T10:46:58","date_gmt":"2025-06-15T08:46:58","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/15\/memory-t-cell-formation-and-phenotype-varies-across-intestinal-compartments-sarah-sandford\/"},"modified":"2025-06-15T10:46:58","modified_gmt":"2025-06-15T08:46:58","slug":"memory-t-cell-formation-and-phenotype-varies-across-intestinal-compartments-sarah-sandford","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/15\/memory-t-cell-formation-and-phenotype-varies-across-intestinal-compartments-sarah-sandford\/","title":{"rendered":"Memory T cell formation and phenotype varies across intestinal compartments. Sarah Sandford"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Jun 12:S1933-0219(25)00065-0. doi: 10.1016\/j.mucimm.2025.06.005. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Numerous studies have shown that tissue-resident memory T (T<sub>RM<\/sub>) cells form in the intestine following pathogen clearance. However, most knowledge of intestinal T<sub>RM<\/sub> cells has derived from analyses restricted to the small intestine (SI). In contrast, less is known about T<sub>RM<\/sub> cell formation in the large intestine (LI). Here, we compared the abundance and phenotype of memory T cells across intestinal compartments. Using mouse models of infection, we observed that fewer memory T cells formed in the LI compared to the SI. Moreover, we found that T cells in the epithelium and lamina propria of the LI colon and caecum were phenotypically distinct from SI counterparts, comprising Ly6C-expressing CD8<sup>+<\/sup> T<sub>RM<\/sub> cells with a distinct cytokine and granzyme profile. Using both loss- and gain-of-function approaches, we identified site-specific TGF-\u03b2 dependencies, whereby Ly6C<sup>+<\/sup>CD103- T<sub>RM<\/sub> cells developed independently of TGF-\u03b2 in both the SI and LI. In contrast, augmenting TGF-\u03b2 signalling preferentially expanded Ly6C<sup>&#8211;<\/sup>T<sub>RM<\/sub>populations in the LI but not the SI, indicating that TGF-\u03b2 signalling drives T<sub>RM<\/sub>cell heterogeneity between these compartments. Together, these findings underscore how regional differences in T<sub>RM<\/sub> cell responsiveness to local cues shape their development, phenotype, and function along the gastrointestinal tract.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40516610\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250615044657&amp;v=2.18.0.post9+e462414\">40516610<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.06.005\">10.1016\/j.mucimm.2025.06.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Jun 12:S1933-0219(25)00065-0. doi: 10.1016\/j.mucimm.2025.06.005. Online ahead of print. ABSTRACT Numerous studies have shown that tissue-resident memory T (TRM) cells form in the intestine following pathogen clearance. However, most knowledge of intestinal TRM cells has derived from analyses restricted to the small intestine (SI). In contrast, less is known about TRM cell formation &#8230; <a title=\"Memory T cell formation and phenotype varies across intestinal compartments. Sarah Sandford\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/15\/memory-t-cell-formation-and-phenotype-varies-across-intestinal-compartments-sarah-sandford\/\" aria-label=\"Read more about Memory T cell formation and phenotype varies across intestinal compartments. Sarah Sandford\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-35417","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=35417"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/35417\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=35417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=35417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=35417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}