{"id":36318,"date":"2025-06-27T00:48:45","date_gmt":"2025-06-26T22:48:45","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/the-complement-regulator-cd55-modulates-tlr9-signaling-and-supports-survival-in-marginal-zone-b-cells\/"},"modified":"2025-06-27T00:48:45","modified_gmt":"2025-06-26T22:48:45","slug":"the-complement-regulator-cd55-modulates-tlr9-signaling-and-supports-survival-in-marginal-zone-b-cells","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/the-complement-regulator-cd55-modulates-tlr9-signaling-and-supports-survival-in-marginal-zone-b-cells\/","title":{"rendered":"The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Jun 16:vkaf124. doi: 10.1093\/jimmun\/vkaf124. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. When unregulated, MZ B cells are associated with autoimmunity. CD55 is a membrane-bound complement regulator that interferes with complement activation and is another important component of innate and adaptive immunity. MZ B cells express low CD55 in both mice and humans, but the role of CD55 in MZ B cell function is unknown. Using germline knockout (KO) mice, we found that similar numbers of MZ B cells were initially established in 3-wk-old CD55-deficient mice compared with wild-type mice. However, MZ B cells failed to accumulate as mice aged and underwent increased apoptosis independent of alternative complement activation. Following ex vivo stimulation of MZ B cells through TLR9 (Toll-like receptor 9), we observed increased interleukin-6 expression in CD55 KO MZ B cells. In addition, CD55 KO mice exhibited reduced total IgG response following in vivo administration of TLR9 agonist. These findings provide new insights into the role of CD55 in MZ B cell survival and B cell function.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40570142\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250626184844&amp;v=2.18.0.post9+e462414\">40570142<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf124\">10.1093\/jimmun\/vkaf124<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Jun 16:vkaf124. doi: 10.1093\/jimmun\/vkaf124. Online ahead of print. ABSTRACT Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. When unregulated, MZ B cells are associated with autoimmunity. CD55 is a membrane-bound complement regulator that interferes with complement activation and is &#8230; <a title=\"The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/the-complement-regulator-cd55-modulates-tlr9-signaling-and-supports-survival-in-marginal-zone-b-cells\/\" aria-label=\"Read more about The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-36318","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36318"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36318\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}