{"id":36403,"date":"2025-06-27T18:47:39","date_gmt":"2025-06-27T16:47:39","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/ageing-affects-the-cd4-t-cell-polarization-and-mucosal-tropism-induced-by-tlr2-tlr4-activated-dendritic-cellssara-zuquete-on-27-de-june-de-2025-at-1000\/"},"modified":"2025-06-27T18:47:39","modified_gmt":"2025-06-27T16:47:39","slug":"ageing-affects-the-cd4-t-cell-polarization-and-mucosal-tropism-induced-by-tlr2-tlr4-activated-dendritic-cellssara-zuquete-on-27-de-june-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/ageing-affects-the-cd4-t-cell-polarization-and-mucosal-tropism-induced-by-tlr2-tlr4-activated-dendritic-cellssara-zuquete-on-27-de-june-de-2025-at-1000\/","title":{"rendered":"Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2\/TLR4-activated dendritic cells\u200bSara Z\u00faquete   on 27 de June de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Jun 27:qiaf096. doi: 10.1093\/jleuko\/qiaf096. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (\u03b14\u03b27 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of non-mucosal DCs through TLR2 and TLR4 maintains such capacity while reinforcing the polarization of primed CD4+ T cells towards Th1. Here, we observed that TLR2\/TLR4 stimulation of aged DCs leads to the production of less TNF\u03b1 and more IL-10 and that CD4+ T cells primed by those DCs express lower levels of the mucosal homing receptor CCR9 and produce less type-1 (IFN\u03b3) and more type-2 (IL-4 and IL-13) cytokines. These results emphasize the importance of considering the age-related alterations in DC function when developing novel immunomodulation strategies that rely on the DC-T cell crosstalk through stimulation of pattern recognition receptors.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40576094\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250627124737&amp;v=2.18.0.post9+e462414\">40576094<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf096\">10.1093\/jleuko\/qiaf096<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Jun 27:qiaf096. doi: 10.1093\/jleuko\/qiaf096. Online ahead of print. ABSTRACT Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (\u03b14\u03b27 and CCR9) in the activated T cells. Recently, we have shown &#8230; <a title=\"Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2\/TLR4-activated dendritic cells\u200bSara Z\u00faquete   on 27 de June de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/06\/27\/ageing-affects-the-cd4-t-cell-polarization-and-mucosal-tropism-induced-by-tlr2-tlr4-activated-dendritic-cellssara-zuquete-on-27-de-june-de-2025-at-1000\/\" aria-label=\"Read more about Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2\/TLR4-activated dendritic cells\u200bSara Z\u00faquete   on 27 de June de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-36403","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36403"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36403\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}