{"id":36588,"date":"2025-07-01T11:48:18","date_gmt":"2025-07-01T09:48:18","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/mhc-ii-restricted-presentation-of-soluble-antigen-by-naive-b-cells-is-impaired-upon-engagement-with-membrane-associated-antigen-a-potential-mechanism-to-mitigate-autoreactivity\/"},"modified":"2025-07-01T11:48:18","modified_gmt":"2025-07-01T09:48:18","slug":"mhc-ii-restricted-presentation-of-soluble-antigen-by-naive-b-cells-is-impaired-upon-engagement-with-membrane-associated-antigen-a-potential-mechanism-to-mitigate-autoreactivity","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/mhc-ii-restricted-presentation-of-soluble-antigen-by-naive-b-cells-is-impaired-upon-engagement-with-membrane-associated-antigen-a-potential-mechanism-to-mitigate-autoreactivity\/","title":{"rendered":"MHC II-restricted presentation of soluble antigen by na\u00efve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Jun 23:vkaf129. doi: 10.1093\/jimmun\/vkaf129. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>T cell tolerance to self can prevent self-reactive B cells from mounting effective autoimmune responses by limiting their available help. However, tolerance may be compromised during infection if small amounts of soluble cross-reactive pathogen antigens containing functional T cell epitopes are released for capture by activated B cells. Here, we assess this scenario and show that na\u00efve B cells engaged and activated by membrane-bound antigens lacking T helper epitopes are impaired in their ability to capture and present additional soluble antigens containing T helper epitopes. This limits their ability to acquire help from cognate CD4+ T cells required for effective antibody responses. Failure to capture and present soluble antigen is due to IgM and IgD downregulation when engaged with membrane-bound antigen. Interestingly, IgG+ B cells are not similarly constrained and effectively capture soluble antigens. Our findings suggest control of na\u00efve B cell tolerance partially depends on efficient receptor downregulation upon antigen engagement.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40581630\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250701054817&amp;v=2.18.0.post9+e462414\">40581630<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf129\">10.1093\/jimmun\/vkaf129<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Jun 23:vkaf129. doi: 10.1093\/jimmun\/vkaf129. Online ahead of print. ABSTRACT T cell tolerance to self can prevent self-reactive B cells from mounting effective autoimmune responses by limiting their available help. However, tolerance may be compromised during infection if small amounts of soluble cross-reactive pathogen antigens containing functional T cell epitopes are released for &#8230; <a title=\"MHC II-restricted presentation of soluble antigen by na\u00efve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/mhc-ii-restricted-presentation-of-soluble-antigen-by-naive-b-cells-is-impaired-upon-engagement-with-membrane-associated-antigen-a-potential-mechanism-to-mitigate-autoreactivity\/\" aria-label=\"Read more about MHC II-restricted presentation of soluble antigen by na\u00efve B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-36588","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36588"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36588\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}