{"id":36608,"date":"2025-07-01T15:48:52","date_gmt":"2025-07-01T13:48:52","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/early-increased-monocyte-to-lymphocyte-ratio-as-a-potential-biomarker-of-bacterial-sepsis-in-patients-with-severe-covid-19edna-basilio-galvez-on-1-de-july-de-2025-at-1000-2\/"},"modified":"2025-07-01T15:48:52","modified_gmt":"2025-07-01T13:48:52","slug":"early-increased-monocyte-to-lymphocyte-ratio-as-a-potential-biomarker-of-bacterial-sepsis-in-patients-with-severe-covid-19edna-basilio-galvez-on-1-de-july-de-2025-at-1000-2","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/early-increased-monocyte-to-lymphocyte-ratio-as-a-potential-biomarker-of-bacterial-sepsis-in-patients-with-severe-covid-19edna-basilio-galvez-on-1-de-july-de-2025-at-1000-2\/","title":{"rendered":"Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19\u200bEdna Basilio-G\u00e1lvez   on 1 de July de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Jun 4;117(6):qiaf064. doi: 10.1093\/jleuko\/qiaf064.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. Twenty-nine patients with COVID-19, 9 patients with COVID-19 + sepsis, and 11 non-COVID nonseptic volunteers were recruited. Patients with COVID-19 + sepsis had increased monocyte count (P = 0.004) and monocyte-to-lymphocyte ratio (MLR, P = 0.01) prior to bacterial sepsis development. The monocyte-to-lymphocyte ratio had an area under the curve of 77.8%, suggesting its potential utility in predicting bacterial sepsis up to 21 d before positive culture. In these patients, smaller intermediate and nonclassical monocytes expressed higher levels of HLA-DR (P &lt; 0.05). Diminished HLA-DR expression in bigger monocytes was associated with an increase in severity and inflammatory markers (r2 values equal to or higher than \u00b10.4, P &lt; 0.05). Our results suggest that the monocyte-to-lymphocyte ratio could be a potential early marker for bacterial sepsis development in patients with severe COVID-19.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40590123\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250701094850&amp;v=2.18.0.post9+e462414\">40590123<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf064\">10.1093\/jleuko\/qiaf064<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093\/jleuko\/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. &#8230; <a title=\"Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19\u200bEdna Basilio-G\u00e1lvez   on 1 de July de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/01\/early-increased-monocyte-to-lymphocyte-ratio-as-a-potential-biomarker-of-bacterial-sepsis-in-patients-with-severe-covid-19edna-basilio-galvez-on-1-de-july-de-2025-at-1000-2\/\" aria-label=\"Read more about Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19\u200bEdna Basilio-G\u00e1lvez   on 1 de July de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-36608","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36608"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36608\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}