{"id":36863,"date":"2025-07-04T06:48:04","date_gmt":"2025-07-04T04:48:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/extracellular-vesicle-impact-on-immunity-following-blood-transfusion\/"},"modified":"2025-07-04T06:48:04","modified_gmt":"2025-07-04T04:48:04","slug":"extracellular-vesicle-impact-on-immunity-following-blood-transfusion","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/extracellular-vesicle-impact-on-immunity-following-blood-transfusion\/","title":{"rendered":"Extracellular vesicle impact on immunity following blood transfusion"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Jul 2;95:102603. doi: 10.1016\/j.coi.2025.102603. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>PURPOSE OF THE REVIEW: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage.<\/p>\n<p>RECENT FINDINGS: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as lipid mediators and expressing adhesion molecules, EVs contribute to immune signaling via cytokines, DAMPs, and antigen-presenting molecules. In RBC, EVs accumulate during storage and are linked to endothelial cell (EC) activation, increased thrombotic risk, and tissue inflammation &#8211; especially under existing inflammatory conditions. While their effect on circulating immune cells is limited, they strongly activate tissue-resident immune and EC. In PCs, platelet-derived EVs and other cell-specific EVs also emerge. Certain EV subtypes express CD27, CD70, CD39, and HLA antigens, altering T-cell, B-cell, and monocyte activity. These immunomodulatory effects may contribute to transfusion-related immunomodulation and alloimmunization.<\/p>\n<p>SUMMARY: EVs in stored blood products influence immune responses highlighting the need for monitoring.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40609228\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250704004803&amp;v=2.18.0.post9+e462414\">40609228<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102603\">10.1016\/j.coi.2025.102603<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Jul 2;95:102603. doi: 10.1016\/j.coi.2025.102603. Online ahead of print. ABSTRACT PURPOSE OF THE REVIEW: Recent insights into extracellular vesicles (EVs) derived from platelet (PC) and red blood cell concentrates (RBC), which form during blood product processing and storage. RECENT FINDINGS: EVs impact transfusion outcomes by modulating immune and inflammatory responses. Acting as &#8230; <a title=\"Extracellular vesicle impact on immunity following blood transfusion\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/extracellular-vesicle-impact-on-immunity-following-blood-transfusion\/\" aria-label=\"Read more about Extracellular vesicle impact on immunity following blood transfusion\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-36863","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36863"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36863\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}