{"id":36918,"date":"2025-07-04T12:51:06","date_gmt":"2025-07-04T10:51:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/il-21-contributes-to-type-2-memory-b-cell-formation\/"},"modified":"2025-07-04T12:51:06","modified_gmt":"2025-07-04T10:51:06","slug":"il-21-contributes-to-type-2-memory-b-cell-formation","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/il-21-contributes-to-type-2-memory-b-cell-formation\/","title":{"rendered":"IL-21 contributes to type 2 memory B cell formation"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Jul 3:vkaf147. doi: 10.1093\/jimmun\/vkaf147. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4R\u03b1+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma cells (PC) and considered key in allergy. While IL-21 is critical for normal mBC differentiation, its involvement in mBC2 formation is unknown. Here, we show that although IL-21R-deficient (IL-21R-\/-) mice immunized with ovalbumin generated ovalbumin-specific mBC2, their abundances were lower than in controls one-week post-immunization. This deficit was associated with the accumulation of pre-prememory GC B cells and corresponding deficiencies in pre-memory B cell exit, suggesting a defect in memory differentiation. Germinal centers waned rapidly in IL-21R-\/- mice and subsequently mBC2 numbers diminished, and IgG1 PC genesis was suppressed. These data show that IL-21 is required for normal mBC2 formation, arguing against the use of IL-21 as a pan-allergy suppressor.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40611513\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250704065103&amp;v=2.18.0.post9+e462414\">40611513<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf147\">10.1093\/jimmun\/vkaf147<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Jul 3:vkaf147. doi: 10.1093\/jimmun\/vkaf147. Online ahead of print. ABSTRACT Type 2 memory B cells (mBC2), identified in mice as IgG1+CD23+IL-4R\u03b1+CD38+ B cells, which require IL-4 for genesis, are precursors for IgE plasma cells (PC) and considered key in allergy. While IL-21 is critical for normal mBC differentiation, its involvement in mBC2 formation &#8230; <a title=\"IL-21 contributes to type 2 memory B cell formation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/04\/il-21-contributes-to-type-2-memory-b-cell-formation\/\" aria-label=\"Read more about IL-21 contributes to type 2 memory B cell formation\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-36918","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36918"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36918\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}