{"id":36961,"date":"2025-07-06T12:48:53","date_gmt":"2025-07-06T10:48:53","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/06\/development-and-consequences-of-red-blood-cell-autoantibodies-warm-autoimmune-hemolytic-anemia\/"},"modified":"2025-07-06T12:48:53","modified_gmt":"2025-07-06T10:48:53","slug":"development-and-consequences-of-red-blood-cell-autoantibodies-warm-autoimmune-hemolytic-anemia","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/06\/development-and-consequences-of-red-blood-cell-autoantibodies-warm-autoimmune-hemolytic-anemia\/","title":{"rendered":"Development and consequences of red blood cell autoantibodies: warm autoimmune hemolytic anemia"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Jul 3;95:102604. doi: 10.1016\/j.coi.2025.102604. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Autoimmune hemolytic anemia (AIHA) is a rare disorder caused by loss of tolerance to red blood cell (RBC) antigens, leading to their destruction by autoantibodies. AIHA can occur as a primary condition or secondary to infections, malignancies, or immune-modulating therapies, such as immune checkpoint inhibitors. This review focuses on the roles of B and T cells in disease initiation and progression of warm AIHA. We discuss recent studies highlighting the importance of dysregulated CD4+ T cells in driving autoreactive B cell responses and autoantibody production and highlight a new role for purinergic signaling in contributing to T cell dysfunction. This dysfunction results in an imbalance between T regulatory cells and proinflammatory Th17 cells, further exacerbating the autoimmune response. Treatment strategies have variable success, with relapse rates of up to 50% and mortality in \u223c11%. As such, we also discuss emerging therapeutic strategies, which may potentially lead to more effective and targeted treatments for this serious condition.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40616920\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250706064852&amp;v=2.18.0.post9+e462414\">40616920<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102604\">10.1016\/j.coi.2025.102604<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Jul 3;95:102604. doi: 10.1016\/j.coi.2025.102604. Online ahead of print. ABSTRACT Autoimmune hemolytic anemia (AIHA) is a rare disorder caused by loss of tolerance to red blood cell (RBC) antigens, leading to their destruction by autoantibodies. AIHA can occur as a primary condition or secondary to infections, malignancies, or immune-modulating therapies, such as &#8230; <a title=\"Development and consequences of red blood cell autoantibodies: warm autoimmune hemolytic anemia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/06\/development-and-consequences-of-red-blood-cell-autoantibodies-warm-autoimmune-hemolytic-anemia\/\" aria-label=\"Read more about Development and consequences of red blood cell autoantibodies: warm autoimmune hemolytic anemia\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-36961","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=36961"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/36961\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=36961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=36961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=36961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}