{"id":38104,"date":"2025-07-13T09:48:10","date_gmt":"2025-07-13T07:48:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/13\/repurposing-of-old-drugs-for-unleashing-innate-immunity-fanchao-meng\/"},"modified":"2025-07-13T09:48:10","modified_gmt":"2025-07-13T07:48:10","slug":"repurposing-of-old-drugs-for-unleashing-innate-immunity-fanchao-meng","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/13\/repurposing-of-old-drugs-for-unleashing-innate-immunity-fanchao-meng\/","title":{"rendered":"Repurposing of old drugs for unleashing innate immunity. Fanchao Meng"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Jul 11:S1471-4906(25)00169-3. doi: 10.1016\/j.it.2025.07.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Pharmacological activation of the stimulator of interferon genes (STING) pathway triggers inflammatory innate immune responses to potentially reinvigorate tumor immunogenicity. Recent work by Dang et al. revealed an alternative paradigm: a clinically approved old drug was repurposed to boost STING signaling and immune activation via a mode of action distinct from that of conventional STING agonists.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40651881\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250713034808&amp;v=2.18.0.post9+e462414\">40651881<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.002\">10.1016\/j.it.2025.07.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Jul 11:S1471-4906(25)00169-3. doi: 10.1016\/j.it.2025.07.002. Online ahead of print. ABSTRACT Pharmacological activation of the stimulator of interferon genes (STING) pathway triggers inflammatory innate immune responses to potentially reinvigorate tumor immunogenicity. Recent work by Dang et al. revealed an alternative paradigm: a clinically approved old drug was repurposed to boost STING signaling and immune &#8230; <a title=\"Repurposing of old drugs for unleashing innate immunity. Fanchao Meng\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/13\/repurposing-of-old-drugs-for-unleashing-innate-immunity-fanchao-meng\/\" aria-label=\"Read more about Repurposing of old drugs for unleashing innate immunity. Fanchao Meng\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-38104","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=38104"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38104\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=38104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=38104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=38104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}