{"id":38551,"date":"2025-07-20T10:02:48","date_gmt":"2025-07-20T08:02:48","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/20\/primed-to-be-primed-a-new-second-phase-benjamin-m-kahn\/"},"modified":"2025-07-20T10:02:48","modified_gmt":"2025-07-20T08:02:48","slug":"primed-to-be-primed-a-new-second-phase-benjamin-m-kahn","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/20\/primed-to-be-primed-a-new-second-phase-benjamin-m-kahn\/","title":{"rendered":"Primed to be primed: a new, second phase. Benjamin M Kahn"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Jul 18:S1471-4906(25)00173-5. doi: 10.1016\/j.it.2025.07.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>CD8 T cell activation and acquisition of cytolytic activity, which is essential for adaptive immunity, begins with priming in the lymph node (LN). Jobin et al. recently identified a second, delayed priming phase driven by competition with regulatory T cells for IL-2, revealing a rate-limiting step with significant clinical implications.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40683779\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250720040246&amp;v=2.18.0.post9+e462414\">40683779<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.006\">10.1016\/j.it.2025.07.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Jul 18:S1471-4906(25)00173-5. doi: 10.1016\/j.it.2025.07.006. Online ahead of print. ABSTRACT CD8 T cell activation and acquisition of cytolytic activity, which is essential for adaptive immunity, begins with priming in the lymph node (LN). Jobin et al. recently identified a second, delayed priming phase driven by competition with regulatory T cells for IL-2, revealing &#8230; <a title=\"Primed to be primed: a new, second phase. Benjamin M Kahn\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/20\/primed-to-be-primed-a-new-second-phase-benjamin-m-kahn\/\" aria-label=\"Read more about Primed to be primed: a new, second phase. Benjamin M Kahn\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-38551","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=38551"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38551\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=38551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=38551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=38551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}