{"id":38606,"date":"2025-07-21T10:47:28","date_gmt":"2025-07-21T08:47:28","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/21\/homozygosity-for-the-common-il23r-r381q-variant-associates-with-increased-susceptibility-to-chronic-mucocutaneous-candidiasis-valuemargaux-gerbaux-frederik-staels-mathijs-willemsen-ju\/"},"modified":"2025-07-21T10:47:28","modified_gmt":"2025-07-21T08:47:28","slug":"homozygosity-for-the-common-il23r-r381q-variant-associates-with-increased-susceptibility-to-chronic-mucocutaneous-candidiasis-valuemargaux-gerbaux-frederik-staels-mathijs-willemsen-ju","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/21\/homozygosity-for-the-common-il23r-r381q-variant-associates-with-increased-susceptibility-to-chronic-mucocutaneous-candidiasis-valuemargaux-gerbaux-frederik-staels-mathijs-willemsen-ju\/","title":{"rendered":"Homozygosity for the Common IL23R R381Q Variant Associates with Increased Susceptibility to Chronic Mucocutaneous Candidiasis. [[{&#8220;value&#8221;:&#8221;Margaux Gerbaux, \nFrederik Staels, \nMathijs Willemsen, \nJulika Neumann, \nLeoni B\u00fccken, \nLize Van Meerbeeck, \nWillem Roosens, \nAdrian Liston, \nSt\u00e9phanie Humblet\u2010Baron, \nRik Schrijvers&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/9a8c2886-4036-424c-bfaf-31c3f121fc09\/eji70002-gra-0001-m.png\" alt=\"Homozygosity for the Common IL23R R381Q Variant Associates with Increased Susceptibility to Chronic Mucocutaneous Candidiasis\" \/><\/p>\n<p>Chronic mucocutaneous candidiasis can be caused by an Inborn Error of Immunity, especially those affecting TH-17 \/ IL-17 responses. Through in-depth immunophenotyping and functional assays, we reveal the association between homozygous carriage of the common p.R381Q IL-23R genetic variant and increased candidiasis susceptibility, relying on disrupted IL-23-mediated IL-17 immunity.<\/p>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Chronic mucocutaneous candidiasis can be caused by an Inborn Error of Immunity, especially those affecting TH-17 \/ IL-17 responses. Through in-depth immunophenotyping and functional assays, we reveal the association between homozygous carriage of the common p.R381Q IL-23R genetic variant and increased candidiasis susceptibility, relying on disrupted IL-23-mediated IL-17 immunity.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-38606","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=38606"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38606\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=38606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=38606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=38606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}