{"id":38925,"date":"2025-07-25T06:47:02","date_gmt":"2025-07-25T04:47:02","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/07\/25\/cell-intrinsic-cd4-t-cell-tolerance-a-new-frontier-in-therapy-alexandra-cassano\/"},"modified":"2025-07-25T06:47:02","modified_gmt":"2025-07-25T04:47:02","slug":"cell-intrinsic-cd4-t-cell-tolerance-a-new-frontier-in-therapy-alexandra-cassano","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/07\/25\/cell-intrinsic-cd4-t-cell-tolerance-a-new-frontier-in-therapy-alexandra-cassano\/","title":{"rendered":"Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?. Alexandra Cassano"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Jul 23:S1471-4906(25)00168-1. doi: 10.1016\/j.it.2025.07.001. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>CD4 T cell tolerance is essential for immune homeostasis but its mechanisms remain unclear. Although regulatory T cells (Tregs) mediate T cell-extrinsic tolerance, this review emphasizes the CD4 T cell-intrinsic pathways &#8211; anergy and exhaustion &#8211; that are triggered by suboptimal or persistent antigen stimulation. These states share transcriptional and epigenomic features across contexts such as cancer, pregnancy, and transplantation. Instead of being distinct, they form a spectrum of tolerance with potential for therapeutic targeting. CD154 has re-emerged as a promising target, although memory T cell tolerization remains challenging. A deeper understanding of what sustains or reverses CD4 T cell tolerance is key to designing treatments that induce\/maintain tolerance in autoimmunity and transplantation, or restore functionality in cancer and chronic infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40707326\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250725004700&amp;v=2.18.0.post9+e462414\">40707326<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.001\">10.1016\/j.it.2025.07.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Jul 23:S1471-4906(25)00168-1. doi: 10.1016\/j.it.2025.07.001. Online ahead of print. ABSTRACT CD4 T cell tolerance is essential for immune homeostasis but its mechanisms remain unclear. Although regulatory T cells (Tregs) mediate T cell-extrinsic tolerance, this review emphasizes the CD4 T cell-intrinsic pathways &#8211; anergy and exhaustion &#8211; that are triggered by suboptimal or persistent &#8230; <a title=\"Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?. Alexandra Cassano\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/07\/25\/cell-intrinsic-cd4-t-cell-tolerance-a-new-frontier-in-therapy-alexandra-cassano\/\" aria-label=\"Read more about Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?. Alexandra Cassano\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-38925","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=38925"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/38925\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=38925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=38925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=38925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}