{"id":39615,"date":"2025-08-05T10:46:55","date_gmt":"2025-08-05T08:46:55","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/05\/effect-of-aspirin-challenge-on-innate-lymphoid-cells-in-asthma-patients-with-aspirin-hypersensitivity-valueradoslaw-kacorzyk-bogdan-jakiela-alicja-maciejska-agnieszka-s-wegrzyn-ada\/"},"modified":"2025-08-05T10:46:55","modified_gmt":"2025-08-05T08:46:55","slug":"effect-of-aspirin-challenge-on-innate-lymphoid-cells-in-asthma-patients-with-aspirin-hypersensitivity-valueradoslaw-kacorzyk-bogdan-jakiela-alicja-maciejska-agnieszka-s-wegrzyn-ada","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/05\/effect-of-aspirin-challenge-on-innate-lymphoid-cells-in-asthma-patients-with-aspirin-hypersensitivity-valueradoslaw-kacorzyk-bogdan-jakiela-alicja-maciejska-agnieszka-s-wegrzyn-ada\/","title":{"rendered":"Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity. [[{&#8220;value&#8221;:&#8221;Rados\u0142aw Kacorzyk, \nBogdan Jakiela, \nAlicja Maciejska, \nAgnieszka S. W\u0119grzyn, \nAdam \u0106miel, \nMarek Sanak, \nLucyna Mastalerz&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/ba05a206-8a6f-4580-abd3-55a47531337a\/eji70020-gra-0001-m.png\" alt=\"Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity\" \/><\/p>\n<p>In N-ERD patients, oral aspirin-induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin-induced bronchoconstriction.<\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood ILC2 count, in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) after intranasal administration of cyclooxygenase-1 inhibitors. This study aimed to assess the role of blood and sputum ILCs in N-ERD patients during oral aspirin-induced bronchospasm and to compare patients with eosinophilic and noneosinophilic airway inflammatory phenotypes of asthma. Induced sputum, blood, and urine samples were collected in 24 patients with confirmed N-ERD at baseline and during aspirin-induced bronchospasm. Sputum and blood ILC counts were evaluated using flow cytometry. There was a significant increase in blood ILC1 count (<i>p\u00a0<\/i>&lt;\u00a00.001) and percentage (<i>p<\/i> = 0.003) during aspirin-induced bronchospasm. No significant changes in sputum ILCs were observed, but the number of detected ILCs was very low. There was a significant reduction in induced sputum supernatant (ISS) levels of prostaglandins PGE<sub>2<\/sub> (<i>p<\/i> = 0.004) and PGD<sub>2<\/sub> (<i>p<\/i> = 0.045), leukotriene B<sub>4<\/sub> (<i>p<\/i> = 0.045), and 15-oxo-eicosatetraenoic acid (<i>p<\/i> = 0.045) during aspirin-induced bronchospasm. Blood ILC1 count is increased during oral aspirin-induced bronchospasm in patients with N-ERD, but sputum ILC count at baseline is very low. Therefore, no reliable changes in sputum ILC counts can be detected during bronchospasm.<\/p>","protected":false},"excerpt":{"rendered":"<p>In N-ERD patients, oral aspirin-induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin-induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood &#8230; <a title=\"Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity. [[{&#8220;value&#8221;:&#8221;Rados\u0142aw Kacorzyk, \nBogdan Jakiela, \nAlicja Maciejska, \nAgnieszka S. W\u0119grzyn, \nAdam \u0106miel, \nMarek Sanak, \nLucyna Mastalerz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/05\/effect-of-aspirin-challenge-on-innate-lymphoid-cells-in-asthma-patients-with-aspirin-hypersensitivity-valueradoslaw-kacorzyk-bogdan-jakiela-alicja-maciejska-agnieszka-s-wegrzyn-ada\/\" aria-label=\"Read more about Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity. [[{&#8220;value&#8221;:&#8221;Rados\u0142aw Kacorzyk, \nBogdan Jakiela, \nAlicja Maciejska, \nAgnieszka S. W\u0119grzyn, \nAdam \u0106miel, \nMarek Sanak, \nLucyna Mastalerz&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-39615","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=39615"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39615\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=39615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=39615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=39615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}