{"id":39770,"date":"2025-08-07T06:47:21","date_gmt":"2025-08-07T04:47:21","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/07\/can-we-cure-antiphospholipid-syndrome\/"},"modified":"2025-08-07T06:47:21","modified_gmt":"2025-08-07T04:47:21","slug":"can-we-cure-antiphospholipid-syndrome","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/07\/can-we-cure-antiphospholipid-syndrome\/","title":{"rendered":"Can we cure antiphospholipid syndrome?"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Aug 5;96:102610. doi: 10.1016\/j.coi.2025.102610. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Antiphospholipid antibody syndrome (APS) is a vasculopathy with recurrent thrombosis and\/or miscarriages mediated by autoantibodies against PL-binding proteins (aPL), mainly beta2glycoprotein I (\u03b22GPI). While clotting is the key in vascular APS, thrombosis is not critical for placenta pathology. Despite that, anticoagulant\/antiplatelet drugs are the leading treatments, but this is not a &#8216;one-size-fits-all&#8217; therapy, and recurrences are reported. Additional therapies (e.g. antimalarials, statins) and a better characterization of the individual risk profile may improve the outcome. Nevertheless, we are still unable to &#8216;cure&#8217; APS. The ideal target would be aPL suppression. However, immunosuppression or even B-cell therapies are not effective. Targeting CD38 on antibody-producing cells or anti-CD19 CAR-T cell therapy are promising alternatives, as well as the chimeric autoantigen receptor T cell therapy, due to the identification of \u03b22GPI as an APS autoantigen. Further therapies aimed at improving clot lysis or affecting \u03b22GPI\/anti-\u03b22GPI tissue complex formation are appealing preclinical perspectives.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40768877\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250807004718&amp;v=2.18.0.post9+e462414\">40768877<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102610\">10.1016\/j.coi.2025.102610<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Aug 5;96:102610. doi: 10.1016\/j.coi.2025.102610. Online ahead of print. ABSTRACT Antiphospholipid antibody syndrome (APS) is a vasculopathy with recurrent thrombosis and\/or miscarriages mediated by autoantibodies against PL-binding proteins (aPL), mainly beta2glycoprotein I (\u03b22GPI). While clotting is the key in vascular APS, thrombosis is not critical for placenta pathology. Despite that, anticoagulant\/antiplatelet drugs &#8230; <a title=\"Can we cure antiphospholipid syndrome?\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/07\/can-we-cure-antiphospholipid-syndrome\/\" aria-label=\"Read more about Can we cure antiphospholipid syndrome?\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-39770","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=39770"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39770\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=39770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=39770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=39770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}