{"id":39909,"date":"2025-08-08T10:47:30","date_gmt":"2025-08-08T08:47:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/08\/granulysin-antimicrobial-activity-promotes-dormancy-in-mycobacterium-tuberculosis-valuesarah-schmidiger-erin-f-mccaffrey-jan-m-schmidt-owais-abdul-hameed-max-mpina-anneth-tumbo\/"},"modified":"2025-08-08T10:47:30","modified_gmt":"2025-08-08T08:47:30","slug":"granulysin-antimicrobial-activity-promotes-dormancy-in-mycobacterium-tuberculosis-valuesarah-schmidiger-erin-f-mccaffrey-jan-m-schmidt-owais-abdul-hameed-max-mpina-anneth-tumbo","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/08\/granulysin-antimicrobial-activity-promotes-dormancy-in-mycobacterium-tuberculosis-valuesarah-schmidiger-erin-f-mccaffrey-jan-m-schmidt-owais-abdul-hameed-max-mpina-anneth-tumbo\/","title":{"rendered":"Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis. [[{“value”:”Sarah Schmidiger, \nErin F. McCaffrey, \nJan M. Schmidt, \nOwais Abdul Hameed, \nMax Mpina, \nAnneth Tumbo, \nElirehema Mfinanga, \nFrederick Haraka, \nHellen Hiza, \nMohamed Sasamalo, \nJerry Hella, \nMichael Walch, \nJacques Fellay, \nS\u00e9bastien Gagneux, \nKlaus Reither, \nJos\u00e9 M. Carballido, \nAinhoa Arbu\u00e9s, \nDamien Portevin”}]]"},"content":{"rendered":"

\"Granulysin<\/p>\n

Exploiting a high-dimensional mass cytometry approach, we demonstrate that CD56+<\/sup> lymphocytes promote Mycobacterium tuberculosis<\/i> dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. <\/p>\n

<\/p>\n

ABSTRACT<\/h2>\n

Human tuberculosis (TB) caused by Mycobacterium tuberculosis<\/i> (Mtb<\/i>) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb<\/i> as a hideout to persist in a dormant, antibiotic-tolerant state, only to resuscitate upon immunosuppression. The immune determinants of a granulomatous response driving Mtb<\/i> persistence remain elusive. We here generated ex vivo granuloma-like structures from peripheral blood mononuclear cell specimens of TB patients and applied high-dimensional mass cytometry to elucidate immune factors prompting Mtb<\/i> dormancy. Compared with healthy controls, patient-derived specimens rapidly forced Mtb<\/i> to become dormant-like ex vivo. This observation correlated with an enrichment in activated, innate (-like) cytotoxic lymphocytes and required the presence of CD56+<\/sup> lymphocytes or, more specifically, the content of their granules. Finally, we demonstrated that direct exposure to granulysin induces Mtb<\/i> dormancy, thereby unravelling an immune escape mechanism to cytotoxic lymphocyte activity.<\/p>","protected":false},"excerpt":{"rendered":"

Exploiting a high-dimensional mass cytometry approach, we demonstrate that CD56+ lymphocytes promote Mycobacterium tuberculosis dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. ABSTRACT Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-39909","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=39909"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39909\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=39909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=39909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=39909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}