{"id":39942,"date":"2025-08-08T18:38:51","date_gmt":"2025-08-08T16:38:51","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/08\/unlocking-the-immune-response-in-alk-rearranged-lung-adenocarcinoma\/"},"modified":"2025-08-08T18:38:51","modified_gmt":"2025-08-08T16:38:51","slug":"unlocking-the-immune-response-in-alk-rearranged-lung-adenocarcinoma","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/08\/unlocking-the-immune-response-in-alk-rearranged-lung-adenocarcinoma\/","title":{"rendered":"Unlocking the Immune Response in ALK-Rearranged Lung Adenocarcinoma"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2025 Aug 8:OF1-OF2. doi: 10.1158\/2326-6066.CIR-25-0624. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Anaplastic lymphoma kinase-rearranged lung adenocarcinoma (ALK+ LUAD) is currently considered an immune-resistant disease, yet underlying biological mechanisms are largely unknown. In this issue, Arai and colleagues analyzed the tumor microenvironment (TME) in ALK+ LUADs, identifying a myeloid cell-dominant immunosuppressive TME, primarily driven by IL6 secretion. Dual anti-IL6R\/anti-PD-L1 treatment resulted in robust antitumor effect in mouse models, restoring immune sensitivity and tumor control. These findings highlight a promising therapeutic approach to enhance the efficacy of PD-(L)1 inhibitors by reverting TME-mediated immune resistance, reshaping the role of immunotherapy in ALK+ LUADs. See related article by Arai et al., p. XX .<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40778656\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20250808123848&amp;v=2.18.0.post9+e462414\">40778656<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-25-0624\">10.1158\/2326-6066.CIR-25-0624<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2025 Aug 8:OF1-OF2. doi: 10.1158\/2326-6066.CIR-25-0624. Online ahead of print. ABSTRACT Anaplastic lymphoma kinase-rearranged lung adenocarcinoma (ALK+ LUAD) is currently considered an immune-resistant disease, yet underlying biological mechanisms are largely unknown. In this issue, Arai and colleagues analyzed the tumor microenvironment (TME) in ALK+ LUADs, identifying a myeloid cell-dominant immunosuppressive TME, primarily driven &#8230; <a title=\"Unlocking the Immune Response in ALK-Rearranged Lung Adenocarcinoma\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/08\/unlocking-the-immune-response-in-alk-rearranged-lung-adenocarcinoma\/\" aria-label=\"Read more about Unlocking the Immune Response in ALK-Rearranged Lung Adenocarcinoma\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-39942","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=39942"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39942\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=39942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=39942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=39942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}