{"id":39984,"date":"2025-08-09T19:47:37","date_gmt":"2025-08-09T17:47:37","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/09\/advances-in-human-myeloid-engrafting-nsg-sgm3-and-mistrg-mice-hannah-stocks\/"},"modified":"2025-08-09T19:47:37","modified_gmt":"2025-08-09T17:47:37","slug":"advances-in-human-myeloid-engrafting-nsg-sgm3-and-mistrg-mice-hannah-stocks","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/09\/advances-in-human-myeloid-engrafting-nsg-sgm3-and-mistrg-mice-hannah-stocks\/","title":{"rendered":"Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice. Hannah Stocks"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Aug 7:S1471-4906(25)00178-4. doi: 10.1016\/j.it.2025.07.011. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Humanized mouse models with transgenic expression of human myelopoiesis-supporting growth factors have enhanced human myeloid cell engraftment and improved the study of human innate immune responses. Here, we discuss the remaining challenges associated with studying innate immunity in humanized NSG-SGM3 and MISTRG mice, as well as potential advances to overcome them.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40781011\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250809134734&amp;v=2.18.0.post9+e462414\">40781011<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.011\">10.1016\/j.it.2025.07.011<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Aug 7:S1471-4906(25)00178-4. doi: 10.1016\/j.it.2025.07.011. Online ahead of print. ABSTRACT Humanized mouse models with transgenic expression of human myelopoiesis-supporting growth factors have enhanced human myeloid cell engraftment and improved the study of human innate immune responses. Here, we discuss the remaining challenges associated with studying innate immunity in humanized NSG-SGM3 and MISTRG mice, &#8230; <a title=\"Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice. Hannah Stocks\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/09\/advances-in-human-myeloid-engrafting-nsg-sgm3-and-mistrg-mice-hannah-stocks\/\" aria-label=\"Read more about Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice. Hannah Stocks\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-39984","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=39984"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/39984\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=39984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=39984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=39984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}