{"id":40910,"date":"2025-08-15T05:47:36","date_gmt":"2025-08-15T03:47:36","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/15\/balancing-immunity-disease-risk-mutation-can-be-beneficial-xi-lin\/"},"modified":"2025-08-15T05:47:36","modified_gmt":"2025-08-15T03:47:36","slug":"balancing-immunity-disease-risk-mutation-can-be-beneficial-xi-lin","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/15\/balancing-immunity-disease-risk-mutation-can-be-beneficial-xi-lin\/","title":{"rendered":"Balancing immunity: disease risk mutation can be beneficial. Xi Lin"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Aug 13:S1471-4906(25)00174-7. doi: 10.1016\/j.it.2025.07.007. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>An allelic variant of the autophagy gene ATG16L1 (T300A) is a genetic risk factor for Crohn&#8217;s disease. However, over 50% of the global population carries at least one copy. Yao et al. have demonstrated a heterozygote advantage, where the pathogen-protective effect of one allele may outweigh the disease risk in homozygotes.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40813227\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250814234733&amp;v=2.18.0.post9+e462414\">40813227<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.007\">10.1016\/j.it.2025.07.007<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Aug 13:S1471-4906(25)00174-7. doi: 10.1016\/j.it.2025.07.007. Online ahead of print. ABSTRACT An allelic variant of the autophagy gene ATG16L1 (T300A) is a genetic risk factor for Crohn&#8217;s disease. However, over 50% of the global population carries at least one copy. Yao et al. have demonstrated a heterozygote advantage, where the pathogen-protective effect of one &#8230; <a title=\"Balancing immunity: disease risk mutation can be beneficial. Xi Lin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/15\/balancing-immunity-disease-risk-mutation-can-be-beneficial-xi-lin\/\" aria-label=\"Read more about Balancing immunity: disease risk mutation can be beneficial. Xi Lin\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-40910","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/40910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=40910"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/40910\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=40910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=40910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=40910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}