{"id":41015,"date":"2025-08-16T06:48:19","date_gmt":"2025-08-16T04:48:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/16\/b-cell-targeted-therapies-in-autoimmune-skin-disease-current-advances-and-challenges\/"},"modified":"2025-08-16T06:48:19","modified_gmt":"2025-08-16T04:48:19","slug":"b-cell-targeted-therapies-in-autoimmune-skin-disease-current-advances-and-challenges","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/16\/b-cell-targeted-therapies-in-autoimmune-skin-disease-current-advances-and-challenges\/","title":{"rendered":"B cell-targeted therapies in autoimmune skin disease: current advances and challenges"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Aug 14;96:102643. doi: 10.1016\/j.coi.2025.102643. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Autoimmune skin diseases (AISDs) constitute a group of skin disorders driven by B cell-mediated autoimmunity or dysregulation of other immune cell populations. AISD can be further divided into systemic autoimmune disease with skin involvement, such as systemic lupus erythematosus (SLE), and skin-specific autoimmune disease, such as pemphigus vulgaris (PV). Due to autoreactivity, B cells and autoantibody production play a pivotal role in B cell-driven AISDs. B cell-targeted therapies have become a major focus in research and clinical practice. Recent strategies targeting various B cell have shown promise, whereas several challenges remain in the clinical application. Patient heterogeneity results in variable therapeutic outcomes. Additionally, prolonged B cell suppression increases the risk of infections. Here, this review outlines the B cell-targeted therapeutic approaches in AISDs, explore the implications of their variable efficacy, and discuss future directions for development. We aim to provide broader perspectives for advancing targeted therapies in AISDs.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40816134\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250816004816&amp;v=2.18.0.post9+e462414\">40816134<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102643\">10.1016\/j.coi.2025.102643<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Aug 14;96:102643. doi: 10.1016\/j.coi.2025.102643. Online ahead of print. ABSTRACT Autoimmune skin diseases (AISDs) constitute a group of skin disorders driven by B cell-mediated autoimmunity or dysregulation of other immune cell populations. AISD can be further divided into systemic autoimmune disease with skin involvement, such as systemic lupus erythematosus (SLE), and skin-specific &#8230; <a title=\"B cell-targeted therapies in autoimmune skin disease: current advances and challenges\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/16\/b-cell-targeted-therapies-in-autoimmune-skin-disease-current-advances-and-challenges\/\" aria-label=\"Read more about B cell-targeted therapies in autoimmune skin disease: current advances and challenges\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-41015","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41015"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41015\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}