{"id":41240,"date":"2025-08-21T06:48:54","date_gmt":"2025-08-21T04:48:54","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/21\/leukotriene-b4-regulates-t-cell-recognition-and-control-of-mcmv-in-mucosal-tissues-lauren-e-springer\/"},"modified":"2025-08-21T06:48:54","modified_gmt":"2025-08-21T04:48:54","slug":"leukotriene-b4-regulates-t-cell-recognition-and-control-of-mcmv-in-mucosal-tissues-lauren-e-springer","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/21\/leukotriene-b4-regulates-t-cell-recognition-and-control-of-mcmv-in-mucosal-tissues-lauren-e-springer\/","title":{"rendered":"Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues. Lauren E Springer"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Aug 18:S1933-0219(25)00085-6. doi: 10.1016\/j.mucimm.2025.08.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Lipid mediators play important, yet poorly understood roles in regulating immune responses. Cytomegalovirus (CMV) is a herpesvirus that persists in mucosal tissues. Prior work suggests that leukotrienes, a class of inflammatory lipid mediators, contribute to viral control. Infection with murine (M)CMV altered leukotriene and other lipid mediator production in the nasal mucosa, lungs and salivary glands of mice. Mice lacking the receptor for leukotriene B4 (BLT1<sup>-\/-<\/sup>) had increased viral titers at early timepoints in the nasal mucosa and lungs and produced less interferon (IFN)-\u03b3 in both tissues, altering the balance between IFN-\u03b3 and interleukin (IL)-10. Importantly, viral control in BLT1<sup>-\/-<\/sup> mice was restored by IL-10 blockade, showing that leukotriene B4 promotes an optimal IFN-\u03b3\/IL-10 balance in these mucosal sites during acute infection. BLT1<sup>-\/-<\/sup> T cells showed no defects in the ability to produce IFN-\u03b3, but their gene expression profiles suggested reduced activation and altered migratory capacity. MCMV-specific T cells compete for access to infected cells. Remarkably, when in competition with wild-type T cells, BLT1<sup>-\/-<\/sup> T cells competed poorly for antigen, resulting in reduced expansion. These data suggest that leukotriene B4 promotes control of CMV by optimizing T cell encounters with infected targets, maintaining the balance between IFN-\u03b3 and IL-10.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40835209\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250821004851&amp;v=2.18.0.post9+e462414\">40835209<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.08.002\">10.1016\/j.mucimm.2025.08.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Aug 18:S1933-0219(25)00085-6. doi: 10.1016\/j.mucimm.2025.08.002. Online ahead of print. ABSTRACT Lipid mediators play important, yet poorly understood roles in regulating immune responses. Cytomegalovirus (CMV) is a herpesvirus that persists in mucosal tissues. Prior work suggests that leukotrienes, a class of inflammatory lipid mediators, contribute to viral control. Infection with murine (M)CMV altered leukotriene &#8230; <a title=\"Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues. Lauren E Springer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/21\/leukotriene-b4-regulates-t-cell-recognition-and-control-of-mcmv-in-mucosal-tissues-lauren-e-springer\/\" aria-label=\"Read more about Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues. Lauren E Springer\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-41240","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41240","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41240"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41240\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41240"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41240"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41240"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}