{"id":41310,"date":"2025-08-22T06:47:06","date_gmt":"2025-08-22T04:47:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/22\/microbial-regulation-of-serotonin-and-neuroimmune-interactions\/"},"modified":"2025-08-22T06:47:06","modified_gmt":"2025-08-22T04:47:06","slug":"microbial-regulation-of-serotonin-and-neuroimmune-interactions","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/22\/microbial-regulation-of-serotonin-and-neuroimmune-interactions\/","title":{"rendered":"Microbial regulation of serotonin and neuroimmune interactions"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Aug 20;96:102639. doi: 10.1016\/j.coi.2025.102639. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as key molecular players. Serotonin, a tryptophan-derived neurochemical found across the kingdom of life, is increasingly recognized as an important effector molecule central to interkingdom communication. Here, we focus on serotonin as a key factor for microbiome-neuroimmune interaction. We briefly summarize the serotonergic system and the role of the gut microbiome in regulating serotonin bioavailability, which leads to downstream effects on neuroimmune responses and microbial fitness.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40840010\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250822004703&amp;v=2.18.0.post9+e462414\">40840010<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102639\">10.1016\/j.coi.2025.102639<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Aug 20;96:102639. doi: 10.1016\/j.coi.2025.102639. Online ahead of print. ABSTRACT Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as key molecular players. Serotonin, a tryptophan-derived neurochemical found across the kingdom of life, is increasingly &#8230; <a title=\"Microbial regulation of serotonin and neuroimmune interactions\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/22\/microbial-regulation-of-serotonin-and-neuroimmune-interactions\/\" aria-label=\"Read more about Microbial regulation of serotonin and neuroimmune interactions\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-41310","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41310"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41310\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}