{"id":41383,"date":"2025-08-24T06:48:41","date_gmt":"2025-08-24T04:48:41","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/expansion-of-genital-tregs-reduces-neutrophil-influx-and-maintains-mucosal-barrier-integrity-during-inflammatory-bacteria-challenge-faisal-nuhu\/"},"modified":"2025-08-24T06:48:41","modified_gmt":"2025-08-24T04:48:41","slug":"expansion-of-genital-tregs-reduces-neutrophil-influx-and-maintains-mucosal-barrier-integrity-during-inflammatory-bacteria-challenge-faisal-nuhu","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/expansion-of-genital-tregs-reduces-neutrophil-influx-and-maintains-mucosal-barrier-integrity-during-inflammatory-bacteria-challenge-faisal-nuhu\/","title":{"rendered":"Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge. Faisal Nuhu"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Aug 21:S1933-0219(25)00089-3. doi: 10.1016\/j.mucimm.2025.08.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Genital inflammation is associated with increased HIV risk. We previously found that endocervical Tregs correlated with decreased genital inflammation and reduced HIV target cells. IL-2 induces Tregs, and efforts to potentiate its regulatory activities clinically are ongoing. In this study, intraperitoneal administration of IL-2 conjugated to IL-2mAb clone JES6-1A12 (IL2C-trimeric) in estrous-synchronized female FoxP3<sup>GFP<\/sup> mice selectively expanded Tregs in the lower female genital tract, with limited effects on non-Treg cells. IL2C-trimeric increased the expression of GITR on Tregs, and most Tregs expressed tissue residency markers. IL2C-trimeric pre-treatment prevented neutrophil influx during vaginal challenge with both nonoxynol-9 (N-9) and Mobiluncus mulieris, but maintenance of E-cadherin expression and barrier integrity was only observed for M. mulieris and not N-9. Depletion of FoxP3<sup>+<\/sup>Tregs reversed the protective effects of IL2C-trimeric. Thus, induction of Tregs could be a potential strategy to regulate genital inflammation, reduce HIV acquisition risk, and improve reproductive health outcomes in women.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40848948\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250824004837&amp;v=2.18.0.post9+e462414\">40848948<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.08.006\">10.1016\/j.mucimm.2025.08.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Aug 21:S1933-0219(25)00089-3. doi: 10.1016\/j.mucimm.2025.08.006. Online ahead of print. ABSTRACT Genital inflammation is associated with increased HIV risk. We previously found that endocervical Tregs correlated with decreased genital inflammation and reduced HIV target cells. IL-2 induces Tregs, and efforts to potentiate its regulatory activities clinically are ongoing. In this study, intraperitoneal administration of &#8230; <a title=\"Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge. Faisal Nuhu\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/expansion-of-genital-tregs-reduces-neutrophil-influx-and-maintains-mucosal-barrier-integrity-during-inflammatory-bacteria-challenge-faisal-nuhu\/\" aria-label=\"Read more about Expansion of genital Tregs reduces neutrophil influx and maintains mucosal barrier integrity during inflammatory bacteria challenge. Faisal Nuhu\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-41383","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41383"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41383\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}