{"id":41384,"date":"2025-08-24T06:48:41","date_gmt":"2025-08-24T04:48:41","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/mitochondria-and-lysosomes-in-t-cell-immunometabolism-erienne-g-norton\/"},"modified":"2025-08-24T06:48:41","modified_gmt":"2025-08-24T04:48:41","slug":"mitochondria-and-lysosomes-in-t-cell-immunometabolism-erienne-g-norton","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/mitochondria-and-lysosomes-in-t-cell-immunometabolism-erienne-g-norton\/","title":{"rendered":"Mitochondria and lysosomes in T cell immunometabolism. Erienne G Norton"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Aug 22:S1471-4906(25)00181-4. doi: 10.1016\/j.it.2025.07.014. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Metabolic reprogramming and signaling are key orchestrators of T cell immunity. Recent studies have illustrated important roles for intracellular organelles, especially mitochondria and lysosomes, in enforcing T cell metabolism and signaling in response to various extracellular cues. As such, mitochondrial and lysosomal function contributes to adaptive immunity by regulating T cell activation, differentiation, and functional adaptation. In this Review, we discuss how the interplay between organelle biology and metabolism instructs T cell-mediated immunity, with a particular focus on mitochondria and lysosomes. We also summarize how mitochondria and lysosomes, or their crosstalk with other organelles, orchestrate downstream signaling processes and functional reprogramming of T cells. We conclude with a discussion of the pathophysiological outcomes associated with dysregulation of these organelles.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40849263\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250824004838&amp;v=2.18.0.post9+e462414\">40849263<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.07.014\">10.1016\/j.it.2025.07.014<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Aug 22:S1471-4906(25)00181-4. doi: 10.1016\/j.it.2025.07.014. Online ahead of print. ABSTRACT Metabolic reprogramming and signaling are key orchestrators of T cell immunity. Recent studies have illustrated important roles for intracellular organelles, especially mitochondria and lysosomes, in enforcing T cell metabolism and signaling in response to various extracellular cues. As such, mitochondrial and lysosomal function &#8230; <a title=\"Mitochondria and lysosomes in T cell immunometabolism. Erienne G Norton\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/24\/mitochondria-and-lysosomes-in-t-cell-immunometabolism-erienne-g-norton\/\" aria-label=\"Read more about Mitochondria and lysosomes in T cell immunometabolism. Erienne G Norton\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-41384","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41384"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41384\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}