{"id":41391,"date":"2025-08-25T02:49:14","date_gmt":"2025-08-25T00:49:14","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/25\/establishment-of-a-mouse-model-of-sjogren-syndrome-related-interstitial-lung-disease\/"},"modified":"2025-08-25T02:49:14","modified_gmt":"2025-08-25T00:49:14","slug":"establishment-of-a-mouse-model-of-sjogren-syndrome-related-interstitial-lung-disease","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/25\/establishment-of-a-mouse-model-of-sjogren-syndrome-related-interstitial-lung-disease\/","title":{"rendered":"Establishment of a mouse model of Sj\u00f6gren syndrome-related interstitial lung disease"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Aug 24:vkaf211. doi: 10.1093\/jimmun\/vkaf211. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Sj\u00f6gren syndrome-related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial for elucidating disease mechanisms and facilitating the discovery of novel treatments. In this study, we established a SS-ILD mouse model by administering 3 mg\/kg bleomycin (BLM) via tracheal exposure to NOD\/Ltj mice, a spontaneous model of Sj\u00f6gren syndrome, with ICR mice serving as controls. The successful induction of Sj\u00f6gren syndrome was confirmed through histopathology, and SSA\/SSB ELISAs. Following BLM administration, lung inflammation and fibrosis were evaluated in ICR and NOD\/Ltj mice by imaging, histopathology, and flow cytometry. Both ICR and NOD\/Ltj mice developed lung inflammation and fibrosis after BLM exposure. However, NOD\/Ltj mice exhibited a more pronounced immune response in the lung, characterized by increased infiltration of immune cells, including monocytes, monocyte-derived macrophages, dendritic cells, neutrophils, T cells, and B cells. This model successfully recapitulates key features of SS-ILD, including concurrent lymphocyte infiltration in the salivary glands and inflammation and fibrosis in the lungs. This study established a novel SS-ILD mouse model replicating human disease pathology, offering a valuable tool for investigating pathogenesis and advancing therapeutic development.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40849891\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250824204911&amp;v=2.18.0.post9+e462414\">40849891<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf211\">10.1093\/jimmun\/vkaf211<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Aug 24:vkaf211. doi: 10.1093\/jimmun\/vkaf211. Online ahead of print. ABSTRACT Sj\u00f6gren syndrome-related interstitial lung disease (SS-ILD) is a severe complication associated with significant morbidity and mortality. Despite its clinical importance, the underlying pathogenesis remains poorly understood, and effective therapeutic strategies are limited. The development of a reliable animal model for SS-ILD is crucial &#8230; <a title=\"Establishment of a mouse model of Sj\u00f6gren syndrome-related interstitial lung disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/25\/establishment-of-a-mouse-model-of-sjogren-syndrome-related-interstitial-lung-disease\/\" aria-label=\"Read more about Establishment of a mouse model of Sj\u00f6gren syndrome-related interstitial lung disease\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-41391","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41391"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41391\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}