{"id":41584,"date":"2025-08-27T06:52:30","date_gmt":"2025-08-27T04:52:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/08\/27\/b-cell-antigen-presentation-in-central-nervous-system-autoimmunity\/"},"modified":"2025-08-27T06:52:30","modified_gmt":"2025-08-27T04:52:30","slug":"b-cell-antigen-presentation-in-central-nervous-system-autoimmunity","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/08\/27\/b-cell-antigen-presentation-in-central-nervous-system-autoimmunity\/","title":{"rendered":"B-cell antigen presentation in central nervous system autoimmunity"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Aug 25;96:102647. doi: 10.1016\/j.coi.2025.102647. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG<sup>+<\/sup> neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) has expanded our appreciation of the contribution of B cells in multiple CNS autoimmune diseases. B cells have multiple functions in the initiation and propagation of CNS autoimmunity that extend beyond autoantibody production, including bidirectional interactions with T cells via B-cell antigen presentation. A deeper understanding of the cooperation between B cells and T cells in MS, NMO, and MOGAD should permit the development of more effective therapies across CNS autoimmune disorders.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40858096\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250827005227&amp;v=2.18.0.post9+e462414\">40858096<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102647\">10.1016\/j.coi.2025.102647<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Aug 25;96:102647. doi: 10.1016\/j.coi.2025.102647. Online ahead of print. ABSTRACT The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG+ neuromyelitis optica (NMO) and myelin oligodendrocyte &#8230; <a title=\"B-cell antigen presentation in central nervous system autoimmunity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/08\/27\/b-cell-antigen-presentation-in-central-nervous-system-autoimmunity\/\" aria-label=\"Read more about B-cell antigen presentation in central nervous system autoimmunity\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-41584","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=41584"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/41584\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=41584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=41584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=41584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}